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Title: Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment
Authors: Venkatesh, S.K. 
Wang, G. 
Teo, L.L.S. 
Ang, B.W.L. 
Keywords: age
liver stiffness measurement
magnetic resonance elastography
normal healthy subjects
Issue Date: Jan-2014
Citation: Venkatesh, S.K., Wang, G., Teo, L.L.S., Ang, B.W.L. (2014-01). Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment. Journal of Magnetic Resonance Imaging 39 (1) : 1-8. ScholarBank@NUS Repository.
Abstract: Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4-6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within-subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04-2.15 kPa; range 1.68-2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78-0.96) and CV ranged from 2.2%-11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1-8. © 2013 Wiley Periodicals, Inc. Copyright © 2013 Wiley Periodicals, Inc.
Source Title: Journal of Magnetic Resonance Imaging
ISSN: 10531807
DOI: 10.1002/jmri.24084
Appears in Collections:Staff Publications

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