Please use this identifier to cite or link to this item: https://doi.org/10.1172/JCI57144
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dc.titleCeramides as modulators of cellular and whole-body metabolism
dc.contributor.authorBikman, B.T.
dc.contributor.authorSummers, S.A.
dc.date.accessioned2016-06-01T10:31:56Z
dc.date.available2016-06-01T10:31:56Z
dc.date.issued2011-11-01
dc.identifier.citationBikman, B.T., Summers, S.A. (2011-11-01). Ceramides as modulators of cellular and whole-body metabolism. Journal of Clinical Investigation 121 (11) : 4222-4230. ScholarBank@NUS Repository. https://doi.org/10.1172/JCI57144
dc.identifier.issn00219738
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124854
dc.description.abstractNearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites. While the role of these lipids in the regulation of cell growth and death has been studied extensively, recent studies suggest that a primary consequence of ceramide accumulation is an alteration in metabolism. In both cell-autonomous systems and complex organisms, ceramides modify intracellular signaling pathways to slow anabolism, ensuring that catabolism ensues. These ceramide actions have important implications for diseases associated with obesity, such as diabetes and cardiovascular disease.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1172/JCI57144
dc.sourceScopus
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1172/JCI57144
dc.description.sourcetitleJournal of Clinical Investigation
dc.description.volume121
dc.description.issue11
dc.description.page4222-4230
dc.description.codenJCINA
dc.identifier.isiut000296482700004
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