Please use this identifier to cite or link to this item: https://doi.org/10.1152/ajpcell.00481.2009
Title: PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
Authors: Geng, T.
Li, P.
Okutsu, M.
Yin, X.
Kwek, J. 
Zhang, M.
Yan, Z. 
Keywords: Endurance exercise
Gene expression
Remodeling
Signal transduction
Issue Date: Mar-2010
Citation: Geng, T., Li, P., Okutsu, M., Yin, X., Kwek, J., Zhang, M., Yan, Z. (2010-03). PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. American Journal of Physiology - Cell Physiology 298 (3) : C572-C579. ScholarBank@NUS Repository. https://doi.org/10.1152/ajpcell.00481.2009
Abstract: Endurance exercise stimulates peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression in skeletal muscle, and forced expression of PGC-1α changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1α is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that endurance exercise-induced expression of mitochondrial enzymes (cytochrome oxidase IV and cytochrome c) and increases of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31)-positive endothelial cells in skeletal muscle, but not IIb-to-IIa fiber-type transformation, were significantly attenuated in muscle-specific Pgc-1α knockout mice. Interestingly, voluntary running effectively restored the compromised mitochondrial integrity and superoxide dismutase 2 (SOD2) protein expression in skeletal muscle in Pgc-1α knockout mice. Thus, PGC-1α plays a functional role in endurance exercise-induced mitochondrial biogenesis and angiogenesis, but not IIb-to-IIa fiber-type transformation in mouse skeletal muscle, and the improvement of mitochondrial morphology and antioxidant defense in response to endurance exercise may occur independently of PGC-1α function. We conclude that PGC-1α is required for complete skeletal muscle adaptations induced by endurance exercise in mice. Copyright © 2010 American Physiological Society.
Source Title: American Journal of Physiology - Cell Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/124790
ISSN: 03636143
DOI: 10.1152/ajpcell.00481.2009
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

168
checked on May 13, 2021

WEB OF SCIENCETM
Citations

157
checked on May 13, 2021

Page view(s)

57
checked on May 1, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.