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|Title:||PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle||Authors:||Geng, T.
|Issue Date:||Mar-2010||Citation:||Geng, T., Li, P., Okutsu, M., Yin, X., Kwek, J., Zhang, M., Yan, Z. (2010-03). PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. American Journal of Physiology - Cell Physiology 298 (3) : C572-C579. ScholarBank@NUS Repository. https://doi.org/10.1152/ajpcell.00481.2009||Abstract:||Endurance exercise stimulates peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression in skeletal muscle, and forced expression of PGC-1α changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1α is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that endurance exercise-induced expression of mitochondrial enzymes (cytochrome oxidase IV and cytochrome c) and increases of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31)-positive endothelial cells in skeletal muscle, but not IIb-to-IIa fiber-type transformation, were significantly attenuated in muscle-specific Pgc-1α knockout mice. Interestingly, voluntary running effectively restored the compromised mitochondrial integrity and superoxide dismutase 2 (SOD2) protein expression in skeletal muscle in Pgc-1α knockout mice. Thus, PGC-1α plays a functional role in endurance exercise-induced mitochondrial biogenesis and angiogenesis, but not IIb-to-IIa fiber-type transformation in mouse skeletal muscle, and the improvement of mitochondrial morphology and antioxidant defense in response to endurance exercise may occur independently of PGC-1α function. We conclude that PGC-1α is required for complete skeletal muscle adaptations induced by endurance exercise in mice. Copyright © 2010 American Physiological Society.||Source Title:||American Journal of Physiology - Cell Physiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/124790||ISSN:||03636143||DOI:||10.1152/ajpcell.00481.2009|
|Appears in Collections:||Staff Publications|
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