Please use this identifier to cite or link to this item: https://doi.org/10.1128/JVI.00197-13
Title: Immature and mature dengue serotype 1 virus structures provide insight into the maturation process
Authors: Kostyuchenko, V.A. 
Zhang, Q. 
Tan, J.L. 
Ng, T.-S. 
Lok, S.-M. 
Issue Date: Jul-2013
Citation: Kostyuchenko, V.A., Zhang, Q., Tan, J.L., Ng, T.-S., Lok, S.-M. (2013-07). Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. Journal of Virology 87 (13) : 7700-7707. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.00197-13
Abstract: Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. © 2013, American Society for Microbiology.
Source Title: Journal of Virology
URI: http://scholarbank.nus.edu.sg/handle/10635/124733
ISSN: 0022538X
DOI: 10.1128/JVI.00197-13
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