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|Title:||Immature and mature dengue serotype 1 virus structures provide insight into the maturation process||Authors:||Kostyuchenko, V.A.
|Issue Date:||Jul-2013||Citation:||Kostyuchenko, V.A., Zhang, Q., Tan, J.L., Ng, T.-S., Lok, S.-M. (2013-07). Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. Journal of Virology 87 (13) : 7700-7707. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.00197-13||Abstract:||Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. © 2013, American Society for Microbiology.||Source Title:||Journal of Virology||URI:||http://scholarbank.nus.edu.sg/handle/10635/124733||ISSN:||0022538X||DOI:||10.1128/JVI.00197-13|
|Appears in Collections:||Staff Publications|
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