Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijcard.2012.12.084
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dc.titleMyocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction
dc.contributor.authorZhong, L.
dc.contributor.authorNg, K.K.C.
dc.contributor.authorSim, L.L.
dc.contributor.authorAllen, J.C.
dc.contributor.authorLau, Y.H.
dc.contributor.authorSim, D.K.L.
dc.contributor.authorLee, R.K.K.
dc.contributor.authorPoh, K.K.
dc.contributor.authorChua, T.S.J.
dc.contributor.authorKassab, G.S.
dc.contributor.authorKwok, B.W.K.
dc.contributor.authorTan, R.S.
dc.date.accessioned2016-06-01T10:27:34Z
dc.date.available2016-06-01T10:27:34Z
dc.date.issued2013-10-03
dc.identifier.citationZhong, L., Ng, K.K.C., Sim, L.L., Allen, J.C., Lau, Y.H., Sim, D.K.L., Lee, R.K.K., Poh, K.K., Chua, T.S.J., Kassab, G.S., Kwok, B.W.K., Tan, R.S. (2013-10-03). Myocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction. International Journal of Cardiology 168 (3) : 1975-1983. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2012.12.084
dc.identifier.issn01675273
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124732
dc.description.abstractBackground There is a clinical need for a contractility index that reflects myocardial contractile dysfunction even when ejection fraction (EF) is preserved. We used novel relative load-independent global and regional contractility indices to compare left ventricular (LV) contractile function in three groups: heart failure (HF) with preserved ejection fraction (HFPEF), HF with reduced ejection fraction (HFREF) and normal subjects. Also, we determined the associations of these parameters with 3-month and 1-year mortality in HFPEF patients. Methods 199 HFPEF patients [median age (IQR): 75 (67-80) years] and 327 HFREF patients [69 (59-76) years] were recruited following hospitalization for HF; 22 normal control subjects [65 (54-71) years] were recruited for comparison. All patients underwent standard two-dimensional Doppler and tissue Doppler echocardiography to characterize LV dimension, structure, global and regional contractile function. Results The median (IQR) global LV contractility index, dσ*/dtmax was 4.30 s- 1 (3.51-4.57 s- 1) in normal subjects but reduced in HFPEF [2.57 (2.08-3.64)] and HFREF patients [1.77 (1.34-2.30)]. Similarly, median (IQR) regional LV contractility index was 99% (88-104%) in normal subjects and reduced in HFPEF [81% (66-96%)] and HFREF [56% (41-71%)] patients. Multi-variable logistic regression analysis on HFPEF identified sc-mFS < 76% as the most consistent predictor of both 3-month (OR = 7.15, p < 0.05) and 1-year (OR = 2.57, p < 0.05) mortality after adjusting for medical conditions and other echocardiographic measurements. Conclusion Patients with HFPEF exhibited decreased LV global and regional contractility. This population-based study demonstrated that depressed regional contractility index was associated with higher 3-month and 1-year mortality in HFPEF patients. © 2013 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijcard.2012.12.084
dc.sourceScopus
dc.subjectContractility
dc.subjectHeart failure
dc.subjectNormalized wall-stress
dc.subjectPathophysiology
dc.subjectPrognosis
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.ijcard.2012.12.084
dc.description.sourcetitleInternational Journal of Cardiology
dc.description.volume168
dc.description.issue3
dc.description.page1975-1983
dc.description.codenIJCDD
dc.identifier.isiut000326184400047
Appears in Collections:Staff Publications

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