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|Title:||Deconvolution assessment of splenic and splanchnic contributions to portal venous blood flow in liver cirrhosis||Authors:||San Koh, T.
Hua Thng, C.
Pin Choo, S.
Sing Ng, Q.
Mu Koh, D.
Dynamic contrast-enhanced imaging
portal venous blood flow
splenic and splanchnic blood flow
|Issue Date:||May-2011||Citation:||San Koh, T., Hua Thng, C., Hartono, S., Pin Choo, S., Sing Ng, Q., Khoo, J.B.K., Bisdas, S., Mu Koh, D. (2011-05). Deconvolution assessment of splenic and splanchnic contributions to portal venous blood flow in liver cirrhosis. Medical Physics 38 (5) : 2768-2782. ScholarBank@NUS Repository. https://doi.org/10.1118/1.3582691||Abstract:||Purpose: To devise a noninvasive imaging method for resolving the relative contribution of splenic and splanchnic blood flow to portal venous flow and derive quantitative estimates for parameters pertaining to splenic and portal hemodynamics. Methods: Tracer concentration-time curves of the aorta, portal vein, and spleen can be extracted from dynamic contrast-enhanced (DCE) CT or MR images. A combination of two tracer analysis approaches, namely arterial-venous sampling and residual tracer deconvolution, is proposed to model these concentration-time curves and derive hemodynamic parameters pertaining to splenic and portal circulation. Clinical feasibility of the proposed method was explored using DCE CT datasets of eight cirrhotic patients. Monte Carlo simulations were performed to evaluate the confidence of the parameter estimates. Results: Portal blood flow was estimated to be 763.8 438.1 mlmin in cirrhotic patients and the splenic contribution was found to be elevated (0.75 0.22). Estimates of splenic blood flow (582 420 mlmin) and transit time (15.3 10.1 s) in cirrhotic patients were consistent with reported values obtained using duplex Doppler ultrasound and dynamic scintigraphy, respectively. Conclusions: This study shows the feasibility of noninvasive assessment of splenic and portal hemodynamic parameters by DCE imaging using a combination of tracer kinetics modeling techniques. © 2011 American Association of Physicists in Medicine.||Source Title:||Medical Physics||URI:||http://scholarbank.nus.edu.sg/handle/10635/124717||ISSN:||00942405||DOI:||10.1118/1.3582691|
|Appears in Collections:||Staff Publications|
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