Please use this identifier to cite or link to this item:
|Title:||Cerebral white matter hyperintensity in Parkinson's disease: A major risk factor for mild cognitive impairment||Authors:||Kandiah, N.
|Keywords:||Cerebral small vessel disease
Mild cognitive impairment (MCI)
White matter disease
|Issue Date:||Jul-2013||Citation:||Kandiah, N., Mak, E., Ng, A., Huang, S., Au, W.L., Sitoh, Y.Y., Tan, L.C.S. (2013-07). Cerebral white matter hyperintensity in Parkinson's disease: A major risk factor for mild cognitive impairment. Parkinsonism and Related Disorders 19 (7) : 680-683. ScholarBank@NUS Repository. https://doi.org/10.1016/j.parkreldis.2013.03.008||Abstract:||Background: Mild cognitive impairment (MCI) and dementia contribute to a poor quality of life among patients with PD. The influence of cerebral ischemia as a risk factor for MCI in PD has not been adequately investigated. To address this issue, we examined the influence of the volume and distribution of white matter hyperintensity (WMH) as a risk factor for MCI in early PD. Methods: Prospective study of patients with early idiopathic PD. All patients had baseline MRI-FLAIR, clinical assessment and detailed neuropsychological evaluation. Data on demographics, vascular risk factors, cognitive performance and WMH volumes were analyzed. Results: 91 patients; mean age 64.9 years, mean education of 10.5 years. 24 patients fulfilled the Movement Disorder Society criteria for MCI and were classified as PD-MCI while the rest were classified as PD with no cognitive impairment (PD-NCI). Patients with PD-MCI and PD-NCI did not differ in Hoehn&Yahr staging. PD-MCI patients had a higher prevalence of diabetes mellitus, hypertension and hyperlipidemia. PD-MCI patients had significantly greater volume of periventricular (6.04ml vs. 2.66ml, p=0.001) and deep subcortical WMH (2.16 vs.1.44, p=0.002). Regional WMH was significantly greater among PD-MCI in the frontal, parietal and occipital regions. Logistic regression analyses demonstrated WMH to be associated with PD-MCI independent of age, education, and vascular risk factors. Increasing WMH volume was associated with lower performance on executive function, memory and language. Conclusions: WMH is an important risk factor for PD-MCI independent of vascular risk factors. PD patientswith WMH should be regularly screened for MCI. © 2013 Elsevier Ltd.||Source Title:||Parkinsonism and Related Disorders||URI:||http://scholarbank.nus.edu.sg/handle/10635/124698||ISSN:||13538020||DOI:||10.1016/j.parkreldis.2013.03.008|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 15, 2022
WEB OF SCIENCETM
checked on May 6, 2022
checked on May 12, 2022
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.