Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M111.254227
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dc.titlep53-inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation
dc.contributor.authorDeisenroth, C.
dc.contributor.authorItahana, Y.
dc.contributor.authorTollini, L.
dc.contributor.authorJin, A.
dc.contributor.authorZhang, Y.
dc.date.accessioned2016-06-01T10:25:08Z
dc.date.available2016-06-01T10:25:08Z
dc.date.issued2011-08-12
dc.identifier.citationDeisenroth, C., Itahana, Y., Tollini, L., Jin, A., Zhang, Y. (2011-08-12). p53-inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. Journal of Biological Chemistry 286 (32) : 28343-28356. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M111.254227
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124661
dc.description.abstractThe transcription factor p53 plays a critical role in maintaining homeostasis as it relates to cellular growth, proliferation, and metabolism. In an effort to identify novel p53 target genes, a microarray approach was utilized to identify DHRS3 (also known as retSDR1) as a robust candidate gene. DHRS3 is a highly conserved member of the short chain alcohol dehydrogenase/reductase superfamily with a reported role in lipid and retinoid metabolism. Here, we demonstrate that DHRS3 is an endoplasmic reticulum (ER) protein that is shuttled to theERvia an N-terminal endoplasmic reticulum targeting signal. One important function of the ER is synthesis of neutral lipids that are packaged into lipid droplets whose biogenesis occurs from ER-derived membranes. DHRS3 is enriched at focal points of lipid droplet budding where it also localizes to the phospholipid monolayer of ER-derived lipid droplets. p53 promotes lipid droplet accumulation in a manner consistent with DHRS3 enrichment in the ER. As a p53 target gene, the observations of Dhrs3 location and potential function provide novel insight into an unexpected role for p53 in lipid droplet dynamics with implications in cancer cell metabolism and obesity. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M111.254227
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1074/jbc.M111.254227
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume286
dc.description.issue32
dc.description.page28343-28356
dc.description.codenJBCHA
dc.identifier.isiut000293557800051
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