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Title: Central hepatectomy for centrally located malignant liver tumors: A systematic review
Authors: Lee, S.Y. 
Keywords: Central bisegmentectomy
Central hepatectomy
Middle hepatic lobectomy
Segment orientated liver resection
Issue Date: 2014
Citation: Lee, S.Y. (2014). Central hepatectomy for centrally located malignant liver tumors: A systematic review. World Journal of Hepatology 6 (5) : 347-357. ScholarBank@NUS Repository.
Abstract: Aim: To study whether central hepatectomy (CH) can achieve similar overall patient survival and disease-free survival rates as conventional major hepatectomies or not. Methods: A systematic literature search was performed in MEDLINE for articles published from January 1983 to June 2013 to evaluate the evidence for and against CH in the management of central hepatic malignancies and to compare the perioperative variables and outcomes of CH to lobar/extended hemihepatectomy. Results: A total of 895 patients were included from 21 relevant studies. Most of these patients who underwent CH were a sub-cohort of larger liver resection studies. Only 4 studies directly compared Central vs hemi-/extended hepatectomies. The range of operative time for CH was reported to be 115 to 627 min and Pringle's maneuver was used for vascular control in the majority of studies. The mean intraoperative blood loss during CH ranged from 380 to 2450 ml. The reported morbidity rates ranged from 5.1% to 61.1%, the most common surgical complication was bile leakage and the most common cause of mortality was liver failure. Mortality ranged from 0.0% to 7.1% with an overall mortality of 2.3% following CH. The 1-year overall survival (OS) for patients underwent CH for hepatocellular carcinoma ranged from 67% to 94%; with the 3-year and 5-year OS having a reported range of 44% to 66.8%, and 31.7% to 66.8% respectively. Conclusion: Based on current literature, CH is a promising option for anatomical parenchymal-preserving procedure in patients with centrally located liver malignancies; it appears to be safe and comparable in both perioperative, early and long term outcomes when compared to patients undergoing hemi-/extended hepatectomy. More prospective studies are awaited to further define its role. © 2014 Baishideng Publishing Group Inc.
Source Title: World Journal of Hepatology
ISSN: 19485182
DOI: 10.4254/wjh.v6.i5.347
Appears in Collections:Staff Publications

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