Please use this identifier to cite or link to this item: https://doi.org/10.1038/leu.2013.41
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dc.titleType II EATL (epitheliotropic intestinal T-cell lymphoma): A neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype
dc.contributor.authorTan, S.-Y.
dc.contributor.authorChuang, S.-S.
dc.contributor.authorTang, T.
dc.contributor.authorTan, L.
dc.contributor.authorKo, Y.-H.
dc.contributor.authorChuah, K.-L.
dc.contributor.authorNg, S.-B.
dc.contributor.authorChng, W.-J.
dc.contributor.authorGatter, K.
dc.contributor.authorLoong, F.
dc.contributor.authorLiu, Y.-H.
dc.contributor.authorHosking, P.
dc.contributor.authorCheah, P.-L.
dc.contributor.authorTeh, B.-T.
dc.contributor.authorTay, K.
dc.contributor.authorKoh, M.
dc.contributor.authorLim, S.-T.
dc.date.accessioned2016-06-01T10:24:15Z
dc.date.available2016-06-01T10:24:15Z
dc.date.issued2013-08
dc.identifier.citationTan, S.-Y., Chuang, S.-S., Tang, T., Tan, L., Ko, Y.-H., Chuah, K.-L., Ng, S.-B., Chng, W.-J., Gatter, K., Loong, F., Liu, Y.-H., Hosking, P., Cheah, P.-L., Teh, B.-T., Tay, K., Koh, M., Lim, S.-T. (2013-08). Type II EATL (epitheliotropic intestinal T-cell lymphoma): A neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype. Leukemia 27 (8) : 1688-1696. ScholarBank@NUS Repository. https://doi.org/10.1038/leu.2013.41
dc.identifier.issn08876924
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124633
dc.description.abstractIn this multicentre study, we examined 60 cases of Type II enteropathy-associated T-cell lymphoma (EATL) from the Asia-Pacific region by histological review, immunohistochemistry and molecular techniques. Patients were mostly adult males (median age: 58 years, male:female 2.6:1), presenting with abdominal pain (60%), intestinal perforation (40%) and weight loss (28%). None had a history of coeliac disease and the median survival was only 7 months. Histologically, these tumours could be divided into (i) central tumour zone comprising a monotonous population of neoplastic lymphocytes, (ii) peripheral zone featuring stunted villi and morphologically atypical lymphocytes showing epitheliotropism, and (iii) distant mucosa with normal villous architecture and cytologically normal intra-epithelial lymphocytes (IELs). Characterized by extensive nuclear expression of Megakaryocyte-associated tyrosine kinase (MATK) (87%) and usually a CD8 + CD56 + (88%) cytotoxic phenotype, there was frequent aberrant expression of CD20 (24%). T-cell receptor (TCR) expression was silent or not evaluable in 40% but of the remainder, there was predominant expression of TCRαβ over TCRγδ (1.6:1). In keeping with the normal ratio of IEL subsets, CD8 + cases showed predominant CD8αα homodimer expression (77%), regardless of TCR lineage. These tumours constitute a distinct entity from classical EATL, and the pathology may reflect tumour progression from IEL precursors, remnants of which are often seen in the distant mucosa. © 2013 Macmillan Publishers Limited. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/leu.2013.41
dc.sourceScopus
dc.subjectCD8αα
dc.subjectenteropathy
dc.subjectenteropathy-associated T-cell lymphoma
dc.subjectepitheliotropism
dc.subjectlymphoma
dc.subjectpathology
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/leu.2013.41
dc.description.sourcetitleLeukemia
dc.description.volume27
dc.description.issue8
dc.description.page1688-1696
dc.description.codenLEUKE
dc.identifier.isiut000322823200009
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