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Title: Minimal clinically important difference (MCID) for the functional assessment of cancer therapy: Cognitive function (FACT-Cog) in breast cancer patients
Authors: Cheung, Y.T.
Foo, Y.L.
Shwe, M.
Tan, Y.P.
Fan, G.
Yong, W.S.
Madhukumar, P.
Ooi, W.S.
Chay, W.Y.
Dent, R.A. 
Ang, S.F.
Lo, S.K.
Yap, Y.S.
Ng, R. 
Chan, A. 
Keywords: Breast cancer
Cognitive function
Minimal clinically important difference
Quality of life
Issue Date: 2014
Citation: Cheung, Y.T., Foo, Y.L., Shwe, M., Tan, Y.P., Fan, G., Yong, W.S., Madhukumar, P., Ooi, W.S., Chay, W.Y., Dent, R.A., Ang, S.F., Lo, S.K., Yap, Y.S., Ng, R., Chan, A. (2014). Minimal clinically important difference (MCID) for the functional assessment of cancer therapy: Cognitive function (FACT-Cog) in breast cancer patients. Journal of Clinical Epidemiology. ScholarBank@NUS Repository.
Abstract: Objectives: This is the first reported study to determine the minimal clinically important difference (MCID) of Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), a validated subjective neuropsychological instrument designed to evaluate cancer patients' perceived cognitive deterioration. Study Design and Setting: Breast cancer patients (n = 220) completed FACT-Cog and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30) at baseline and at least 3 months later. Anchor-based approach used the validated EORTC-QLQ-C30-Cognitive Functioning scale (EORTC-CF) as the anchor for patients who showed minimal deterioration and a receiver operating characteristic (ROC) curve to identify the optimal MCID cutoff for deterioration. Distribution-based approach used one-third standard deviation (SD), half SD, and one standard error of measurement (SEM) of the total FACT-Cog score (148 points). Results: There was a moderate correlation between changes in FACT-Cog and EORTC-CF scores (r = 0.43; P 
Source Title: Journal of Clinical Epidemiology
ISSN: 08954356
DOI: 10.1016/j.jclinepi.2013.12.011
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