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|Title:||Expression of Fos-like immunoreactivity in the brain and spinal cord of rats following middle cerebral artery occlusion||Authors:||Wu, Y.-P.
|Keywords:||Focal cerebral ischaemia
Middle cerebral artery
Spinal cord neurons
|Issue Date:||1997||Citation:||Wu, Y.-P., Tan, C.-K., Ling, E.-A. (1997). Expression of Fos-like immunoreactivity in the brain and spinal cord of rats following middle cerebral artery occlusion. Experimental Brain Research 115 (1) : 129-136. ScholarBank@NUS Repository. https://doi.org/10.1007/PL00005672||Abstract:||This study examined c-fos protein expression in the brain and spinal cord of rats following permanent occlusion of the middle cerebral artery (MCA) above the rhinal fissure. At 1 h after right-sided MCA occlusion, Fos-like immunoreactivity (Fos-LI) was detected in neurons not only in the ipsilateral cerebral cortex but also in the spinal cord. In the latter, Fos-LI was localized in the nucleus and perikarya of neurons in the grey matter, notably the large motor neurons in the ventral horn. Fos-LI was most intense at 2-4 h, but became undetectable after 48 h in the cerebral cortex and 72 h in the spinal cord. In sham-operated animals, Fos-LI was almost undetectable or virtually absent. It was also not detected in the core territory supplied by the MCA at any time points after arterial occlusion. When the ischaemia-induced neuronal damage in both the cerebral cortex and spinal cord was evaluated by Nissl staining, some neurons appeared atrophic. We conclude that the induction of Fos-LI in neurons of the cerebral cortex and spinal cord is linked respectively to early onset-short stimulation and persistent excitatory or disinhibition phenomenon as a result of focal ischaemic brain injury.||Source Title:||Experimental Brain Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/120741||ISSN:||00144819||DOI:||10.1007/PL00005672|
|Appears in Collections:||Staff Publications|
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