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Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00044-007-9022-y
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dc.titleSynthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation
dc.contributor.authorAnanda Kumar, C.S.
dc.contributor.authorNanjunda Swamy, S.
dc.contributor.authorThimmegowda, N.R.
dc.contributor.authorBenaka Prasad, S.B.
dc.contributor.authorYip, G.W.
dc.contributor.authorRangappa, K.S.
dc.date.accessioned2015-09-07T09:55:26Z
dc.date.available2015-09-07T09:55:26Z
dc.date.issued2007
dc.identifier.citationAnanda Kumar, C.S., Nanjunda Swamy, S., Thimmegowda, N.R., Benaka Prasad, S.B., Yip, G.W., Rangappa, K.S. (2007). Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Medicinal Chemistry Research 16 (4) : 179-187. ScholarBank@NUS Repository. https://doi.org/10.1007/s00044-007-9022-y
dc.identifier.issn10542523
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120667
dc.description.abstractA series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity. © Birkhäuser 2007.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00044-007-9022-y
dc.sourceScopus
dc.subject1-benzhydryl-piperazine derivatives
dc.subjectCell proliferation
dc.subjectMDA-MB-231
dc.subjectSulfonyl chlorides
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1007/s00044-007-9022-y
dc.description.sourcetitleMedicinal Chemistry Research
dc.description.volume16
dc.description.issue4
dc.description.page179-187
dc.description.codenMCREE
dc.identifier.isiut000253091500004
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