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https://doi.org/10.1016/S0959-437X(03)00007-8
Title: | RUNX transcription factors as key targets of TGF-β superfamily signaling | Authors: | Ito, Y. Miyazono, K. |
Issue Date: | 2003 | Citation: | Ito, Y., Miyazono, K. (2003). RUNX transcription factors as key targets of TGF-β superfamily signaling. Current Opinion in Genetics and Development 13 (1) : 43-47. ScholarBank@NUS Repository. https://doi.org/10.1016/S0959-437X(03)00007-8 | Abstract: | The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-β and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-β-induced tumor suppressor pathway. A possible relationship between the TGF-β-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined. | Source Title: | Current Opinion in Genetics and Development | URI: | http://scholarbank.nus.edu.sg/handle/10635/118083 | ISSN: | 0959437X | DOI: | 10.1016/S0959-437X(03)00007-8 |
Appears in Collections: | Staff Publications |
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