RUNX transcription factors as key targets of TGF-β superfamily signaling

Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0959-437X(03)00007-8

Title:	RUNX transcription factors as key targets of TGF-β superfamily signaling
Authors:	Ito, Y. Miyazono, K.
Issue Date:	2003
Citation:	Ito, Y., Miyazono, K. (2003). RUNX transcription factors as key targets of TGF-β superfamily signaling. Current Opinion in Genetics and Development 13 (1) : 43-47. ScholarBank@NUS Repository. https://doi.org/10.1016/S0959-437X(03)00007-8
Abstract:	The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-β and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-β-induced tumor suppressor pathway. A possible relationship between the TGF-β-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.
Source Title:	Current Opinion in Genetics and Development
URI:	http://scholarbank.nus.edu.sg/handle/10635/118083
ISSN:	0959437X
DOI:	10.1016/S0959-437X(03)00007-8
Appears in Collections:	Staff Publications

There are no files associated with this item.

Check