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https://doi.org/10.1186/1477-7525-3-2
DC Field | Value | |
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dc.title | The impact of diabetes mellitus and other chronic medical conditions on health-related quality of life: Is the whole greater than the sum of its parts? | |
dc.contributor.author | Wee, H.-L. | |
dc.contributor.author | Li, S.-C. | |
dc.contributor.author | Fong, K.-Y. | |
dc.contributor.author | Thumboo, J. | |
dc.contributor.author | Cheung, Y.-B. | |
dc.date.accessioned | 2014-12-17T08:58:20Z | |
dc.date.available | 2014-12-17T08:58:20Z | |
dc.date.issued | 2005-01-12 | |
dc.identifier.citation | Wee, H.-L., Li, S.-C., Fong, K.-Y., Thumboo, J., Cheung, Y.-B. (2005-01-12). The impact of diabetes mellitus and other chronic medical conditions on health-related quality of life: Is the whole greater than the sum of its parts?. Health and Quality of Life Outcomes 3. ScholarBank@NUS Repository. https://doi.org/10.1186/1477-7525-3-2 | |
dc.identifier.issn | 14777525 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/117910 | |
dc.description.abstract | Background: Diabetes mellitus (DM) is an important public health concern, the impact of which is increased by the high prevalence of co-existing chronic medical conditions among subjects with DM. The aims of this study were therefore to (1) evaluate the impact of DM and co-existing chronic medical conditions on health-related quality of life (HRQoL) (which could be additive, synergistic or subtractive); (2) to determine the extent to which the SF-6D (a single-index preference measure) captures the multidimensional information provided by the SF-36 (a profile measure). Methods: Using data from a cross-sectional, population-based survey of Chinese, Malay and Indians in Singapore, we developed 9 separate multiple linear regression models, with each SF-36 scale or SF-6D index score being the dependent variable for one model. The influence of DM and a second chronic medical condition (hypertension (HTN), heart disease (HD), musculoskeletal illnesses (MS)) and their interactions were studied after adjusting for the influence of potential confounding variables. Results: Among 5,224 subjects, the prevalence of DM, HTN, HD and MS were 5.9%, 10.7%, 2.4% and 26.6% respectively. DM lowered SF-36 scores by more than 2 points on 3 SF-36 scales and lowered SF6D scores by 0.03 points. Subjects with DM and HTN, DM and HD or DM and MS experienced further lowering of SF-36 scores exceeding 2 points on at least 6 scales and further lowering of SF-6D scores by 0.05, 0.08 and 0.10 points respectively. Generally, DM and co-existing medical conditions exerted additive effects on HRQoL, with the exception of DM and heart disease, where a subtractive effect was noted. SF6D index scores generally reflected the patterns of influence of DM and chronic medical conditions on SF36 scores. Conclusion: DM and chronic medical conditions generally reduced HRQoL in this multiethnic general population in an additive, rather than synergistic or subtractive fashion. In this study, the SF-6D was a reasonably good summary measure for the SF-36. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1186/1477-7525-3-2 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1186/1477-7525-3-2 | |
dc.description.sourcetitle | Health and Quality of Life Outcomes | |
dc.description.volume | 3 | |
dc.identifier.isiut | NOT_IN_WOS | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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2005-impact_diabetes_mellitus_other_chronic-published.pdf | 291.36 kB | Adobe PDF | OPEN | Published | View/Download |
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