Please use this identifier to cite or link to this item: https://doi.org/10.1186/1477-7525-3-2
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dc.titleThe impact of diabetes mellitus and other chronic medical conditions on health-related quality of life: Is the whole greater than the sum of its parts?
dc.contributor.authorWee, H.-L.
dc.contributor.authorLi, S.-C.
dc.contributor.authorFong, K.-Y.
dc.contributor.authorThumboo, J.
dc.contributor.authorCheung, Y.-B.
dc.date.accessioned2014-12-17T08:58:20Z
dc.date.available2014-12-17T08:58:20Z
dc.date.issued2005-01-12
dc.identifier.citationWee, H.-L., Li, S.-C., Fong, K.-Y., Thumboo, J., Cheung, Y.-B. (2005-01-12). The impact of diabetes mellitus and other chronic medical conditions on health-related quality of life: Is the whole greater than the sum of its parts?. Health and Quality of Life Outcomes 3. ScholarBank@NUS Repository. https://doi.org/10.1186/1477-7525-3-2
dc.identifier.issn14777525
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117910
dc.description.abstractBackground: Diabetes mellitus (DM) is an important public health concern, the impact of which is increased by the high prevalence of co-existing chronic medical conditions among subjects with DM. The aims of this study were therefore to (1) evaluate the impact of DM and co-existing chronic medical conditions on health-related quality of life (HRQoL) (which could be additive, synergistic or subtractive); (2) to determine the extent to which the SF-6D (a single-index preference measure) captures the multidimensional information provided by the SF-36 (a profile measure). Methods: Using data from a cross-sectional, population-based survey of Chinese, Malay and Indians in Singapore, we developed 9 separate multiple linear regression models, with each SF-36 scale or SF-6D index score being the dependent variable for one model. The influence of DM and a second chronic medical condition (hypertension (HTN), heart disease (HD), musculoskeletal illnesses (MS)) and their interactions were studied after adjusting for the influence of potential confounding variables. Results: Among 5,224 subjects, the prevalence of DM, HTN, HD and MS were 5.9%, 10.7%, 2.4% and 26.6% respectively. DM lowered SF-36 scores by more than 2 points on 3 SF-36 scales and lowered SF6D scores by 0.03 points. Subjects with DM and HTN, DM and HD or DM and MS experienced further lowering of SF-36 scores exceeding 2 points on at least 6 scales and further lowering of SF-6D scores by 0.05, 0.08 and 0.10 points respectively. Generally, DM and co-existing medical conditions exerted additive effects on HRQoL, with the exception of DM and heart disease, where a subtractive effect was noted. SF6D index scores generally reflected the patterns of influence of DM and chronic medical conditions on SF36 scores. Conclusion: DM and chronic medical conditions generally reduced HRQoL in this multiethnic general population in an additive, rather than synergistic or subtractive fashion. In this study, the SF-6D was a reasonably good summary measure for the SF-36.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1186/1477-7525-3-2
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentPHARMACY
dc.description.doi10.1186/1477-7525-3-2
dc.description.sourcetitleHealth and Quality of Life Outcomes
dc.description.volume3
dc.identifier.isiutNOT_IN_WOS
dc.published.statePublished
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