Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0002-9343(03)00353-X
DC FieldValue
dc.titleEpidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease
dc.contributor.authorTan, W.C.
dc.contributor.authorXiang, X.
dc.contributor.authorQiu, D.
dc.contributor.authorNg, T.P.
dc.contributor.authorLam, S.F.
dc.contributor.authorHegele, R.G.
dc.date.accessioned2014-12-17T08:55:32Z
dc.date.available2014-12-17T08:55:32Z
dc.date.issued2003
dc.identifier.citationTan, W.C., Xiang, X., Qiu, D., Ng, T.P., Lam, S.F., Hegele, R.G. (2003). Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. American Journal of Medicine 115 (4) : 272-277. ScholarBank@NUS Repository. https://doi.org/10.1016/S0002-9343(03)00353-X
dc.identifier.issn00029343
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117663
dc.description.abstractPurpose: We compared the prevalence and spectrum of common respiratory viruses among patients with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease (COPD), and the relation of these findings to acute respiratory symptoms. Methods: We obtained adequate samples of respiratory secretions from 17 patients hospitalized with near-fatal asthma, 29 with acute asthma, and 14 with COPD. We used a polymerase chain reaction-based method to test for six common respiratory viruses in samples from endotracheal tube aspirates from patients with near-fatal asthma, and from induced sputum specimens from patients with acute asthma or COPD. Respiratory symptoms (runny nose, sore throat, fever, chills, malaise, and cough) were recorded. Quiescent-phase induced sputum specimens were examined from patients who were initially virus positive. Results: Viral nucleic acids were detected in 52% (31/60) of acute-phase specimens and 7% (2/29) of quiescent-phase specimens examined (P <0.001), with similar proportions of virus-positive patients during the acute phase in the three groups: 59% (10/17) of those with near-fatal asthma, 41% (12/29) with acute asthma, and 64% (9/14) with COPD. Picornavirus (47% [n = 8]) and adenovirus (24% [n = 4]) were most commonly identified in near-fatal asthma, whereas influenza virus (36% [n = 5]) predominated in COPD. Virus-positive patients had a significantly increased frequency of runny nose, sore throat, fever, chills, and malaise (odds ratio = 4.1 to 18; P = 0.02 to 0.001). Conclusion: Respiratory viruses are associated with hospitalizations for near-fatal asthma, acute asthma, and COPD, with some differences in the spectrum of viruses involved in the different groups of patients. Respiratory viruses are a target for the prevention and perhaps the treatment of these conditions. © 2003 by Excerpta Medica Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0002-9343(03)00353-X
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1016/S0002-9343(03)00353-X
dc.description.sourcetitleAmerican Journal of Medicine
dc.description.volume115
dc.description.issue4
dc.description.page272-277
dc.description.codenAJMEA
dc.identifier.isiut000185332100003
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