Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0092-8674(02)01111-X
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dc.titleDifferential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
dc.contributor.authorTaniuchi, I.
dc.contributor.authorEgawa, T.
dc.contributor.authorSunshine, M.J.
dc.contributor.authorLittman, D.R.
dc.contributor.authorOsato, M.
dc.contributor.authorIto, Y.
dc.contributor.authorBae, S.-C.
dc.contributor.authorKomori, T.
dc.date.accessioned2014-12-17T08:55:05Z
dc.date.available2014-12-17T08:55:05Z
dc.date.issued2002
dc.identifier.citationTaniuchi, I., Egawa, T., Sunshine, M.J., Littman, D.R., Osato, M., Ito, Y., Bae, S.-C., Komori, T. (2002). Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111 (5) : 621-633. ScholarBank@NUS Repository. https://doi.org/10.1016/S0092-8674(02)01111-X
dc.identifier.issn00928674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117622
dc.description.abstractT lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking CD4 and CD8 coreceptors differentiate into double-positive cells (CD4+CD8+), which are selected to become either CD4+CD8-helper cells or CD4-CD8+ cytotoxic cells. A stage-specific transcriptional silencer regulates expression of CD4 in both immature and CD4-CD8+ thymocytes. We show here that binding sites for Runt domain transcription factors are essential for CD4 silencer function at both stages, and that different Runx family members are required to fulfill unique functions at each stage. Runx1 is required for active repression in CD4-CD8- thymocytes whereas Runx3 is required for establishing epigenetic silencing in cytotoxic lineage thymocytes. Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0092-8674(02)01111-X
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/S0092-8674(02)01111-X
dc.description.sourcetitleCell
dc.description.volume111
dc.description.issue5
dc.description.page621-633
dc.description.codenCELLB
dc.identifier.isiut000179594500005
Appears in Collections:Staff Publications

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