Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.febslet.2013.10.025
DC Field | Value | |
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dc.title | Tapping the treasure of intracellular oncotargets with immunotherapy | |
dc.contributor.author | Hong, C.W. | |
dc.contributor.author | Zeng, Q. | |
dc.date.accessioned | 2014-12-12T08:04:40Z | |
dc.date.available | 2014-12-12T08:04:40Z | |
dc.date.issued | 2014-01-21 | |
dc.identifier.citation | Hong, C.W., Zeng, Q. (2014-01-21). Tapping the treasure of intracellular oncotargets with immunotherapy. FEBS Letters 588 (2) : 350-355. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.10.025 | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/117358 | |
dc.description.abstract | It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.febslet.2013.10.025 | |
dc.source | Scopus | |
dc.subject | Antibody therapy | |
dc.subject | Cancer | |
dc.subject | Extracellular receptor | |
dc.subject | Immunotherapy | |
dc.subject | Intracellular oncotarget | |
dc.subject | Vaccination | |
dc.type | Review | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.description.doi | 10.1016/j.febslet.2013.10.025 | |
dc.description.sourcetitle | FEBS Letters | |
dc.description.volume | 588 | |
dc.description.issue | 2 | |
dc.description.page | 350-355 | |
dc.description.coden | FEBLA | |
dc.identifier.isiut | 000329503100019 | |
Appears in Collections: | Staff Publications |
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