Please use this identifier to cite or link to this item: https://doi.org/10.2174/092986711794927720
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dc.titleComparison of status epilepticus models induced by pilocarpine and nerve agents - A systematic review of the underlying aetiology and adopted therapeutic approaches
dc.contributor.authorTang, F.R.
dc.contributor.authorLoke, W.K.
dc.contributor.authorLing, E.A.
dc.date.accessioned2014-12-12T07:59:40Z
dc.date.available2014-12-12T07:59:40Z
dc.date.issued2011-02
dc.identifier.citationTang, F.R.,Loke, W.K.,Ling, E.A. (2011-02). Comparison of status epilepticus models induced by pilocarpine and nerve agents - A systematic review of the underlying aetiology and adopted therapeutic approaches. Current Medicinal Chemistry 18 (6) : 886-899. ScholarBank@NUS Repository. <a href="https://doi.org/10.2174/092986711794927720" target="_blank">https://doi.org/10.2174/092986711794927720</a>
dc.identifier.issn09298673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116957
dc.description.abstractAmong potential radiological, nuclear, biological and chemical weapons, cholinergic nerve agents from chemical weapons remain a realistic terrorist threat due to its combination of high lethality, demonstrated use and relative abundance of un-destroyed stockpiles in various militaries around the world. While current fielded antidotes are able to mitigate acute poisoning, effective neuroprotection in the field remains a challenge amongst subjects with established status epilepticus following nerve agent intoxication. Due to ethical, safety and surety issues, extensive preclinical and clinical research on cholinergic nerve agents is not possible. This may have been a contributory factor for the slow progress in uncovering new neuroprotectants for nerve agent casualties with established status epilepticus. To overcome this challenge, comparative research with surrogate chemicals that produce similar hypercholinergic toxicity but with less security concerns would be a useful approach forward. In this paper, we will systemically compare the mechanism of seizure generation, propagation and the subsequent clinical, hematologic, and metabolic, biochemical, neuroinflammatory changes and current therapeutic approaches reported in pilocarpine, soman, and sarin models of seizures. This review will be an important first step in closing this knowledge gap among different closely related models of seizures and neurotoxicity. Hopefully, it will spur further efforts in using surrogate cholinergic models by the wider scientific community to expedite the development of a new generation of antidotes that are better able to protect against delayed neurological effects inflicted by nerve agents. © 2011 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/092986711794927720
dc.sourceScopus
dc.subjectMechanism
dc.subjectNerve agents
dc.subjectPilocarpine
dc.subjectStatus epilepticus
dc.subjectSurrogate
dc.subjectTreatment
dc.typeArticle
dc.contributor.departmentTEMASEK LABORATORIES
dc.description.doi10.2174/092986711794927720
dc.description.sourcetitleCurrent Medicinal Chemistry
dc.description.volume18
dc.description.issue6
dc.description.page886-899
dc.description.codenCMCHE
dc.identifier.isiutNOT_IN_WOS
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