Please use this identifier to cite or link to this item:
https://doi.org/10.1111/j.1440-1681.2004.03975.x
DC Field | Value | |
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dc.title | Proteins of the Bcl-2 family in apoptosis signalling: From mechanistic insights to therapeutic opportunities | |
dc.contributor.author | Chan, S.-L. | |
dc.contributor.author | Yu, V.C. | |
dc.date.accessioned | 2014-12-12T07:54:52Z | |
dc.date.available | 2014-12-12T07:54:52Z | |
dc.date.issued | 2004-03 | |
dc.identifier.citation | Chan, S.-L., Yu, V.C. (2004-03). Proteins of the Bcl-2 family in apoptosis signalling: From mechanistic insights to therapeutic opportunities. Clinical and Experimental Pharmacology and Physiology 31 (3) : 119-128. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1440-1681.2004.03975.x | |
dc.identifier.issn | 03051870 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/116851 | |
dc.description.abstract | 1. Proteins of the Bcl-2 family are central regulators of apoptosis and are thought to act primarily on the mitochondria. 2. Members of the Bcl-2 family possess either anti-apoptotic or pro-apoptotic function. They are characterized by the presence of conserved sequence motifs, known as Bcl-2 homology (BH) domains. Anti-apoptotic members share all four BH domains, designated as BH1-4; the multidomain pro-apoptotic members contain BH1-3 domains, whereas another subgroup of pro-apoptotic members only have a BH3 domain. 3. The BH3-only proteins act as sensors for distinct apoptosis pathways, whereas multidomain pro-apoptotic Bax and Bak are executioners of death orders relayed by the BH3-only proteins. 4. Anti-apoptotic Bcl-2 family members appear to function, at least in part, by interacting with and antagonizing pro-apoptotic family members. The BH1-3 domains of BclXL form an elongated hydrophobic groove, which is the docking site for the BH3 domains of pro-apoptotic binding partners. 5. The deregulation of the various Bcl-2 proteins has been implicated in many pathological conditions. 6. Knowledge derived from the understanding of the function and regulation of the Bcl-2 family of proteins has allowed us to contemplate new therapeutic strategies for diseases where apoptosis signalling mechanisms can potentially be manipulated. 7. The anti-apoptotic Bcl-2 members have been targeted successfully using an antisense approach, BH3-peptides and small molecular weight chemicals that are inhibitors of their anti-apoptotic function. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1440-1681.2004.03975.x | |
dc.source | Scopus | |
dc.subject | Antisense | |
dc.subject | Apoptosis | |
dc.subject | Bcl-2 family | |
dc.subject | Cancer | |
dc.subject | Chemical inhibitors | |
dc.subject | Myocardial infarction | |
dc.subject | Therapeutic targets | |
dc.type | Others | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.description.doi | 10.1111/j.1440-1681.2004.03975.x | |
dc.description.sourcetitle | Clinical and Experimental Pharmacology and Physiology | |
dc.description.volume | 31 | |
dc.description.issue | 3 | |
dc.description.page | 119-128 | |
dc.description.coden | CEXPB | |
dc.identifier.isiut | 000220150300001 | |
Appears in Collections: | Staff Publications |
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