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Title: RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors
Authors: Chuang, L.S.H. 
Lai, S.K. 
Murata-Hori, M.
Yamada, A. 
Li, H.-Y.
Gunaratne, J.
Ito, Y.
Keywords: γ-tubulin
Mitotic spindle
Issue Date: 15-May-2012
Citation: Chuang, L.S.H., Lai, S.K., Murata-Hori, M., Yamada, A., Li, H.-Y., Gunaratne, J., Ito, Y. (2012-05-15). RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors. Cell Cycle 11 (10) : 1938-1947. ScholarBank@NUS Repository.
Abstract: RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. Here, we explore the binding partners of RUNX3 proteins to further define the scope of RUNX3 function. Using a mass spectrometry-based approach, we found that RUNX3 binds to centrosomal protein rootletin. This led us to uncover the presence of RUNX proteins at the centrosome. Our findings suggest a potential function for RUNX3 during mitosis. © 2012 Landes Bioscience.
Source Title: Cell Cycle
ISSN: 15384101
DOI: 10.4161/cc.20278
Appears in Collections:Staff Publications

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