Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cub.2012.01.061
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dc.titleChondroitin fragments are odorants that trigger fear behavior in fish
dc.contributor.authorMathuru, A.S.
dc.contributor.authorKibat, C.
dc.contributor.authorCheong, W.F.
dc.contributor.authorShui, G.
dc.contributor.authorWenk, M.R.
dc.contributor.authorFriedrich, R.W.
dc.contributor.authorJesuthasan, S.
dc.date.accessioned2014-12-12T07:47:41Z
dc.date.available2014-12-12T07:47:41Z
dc.date.issued2012-03-20
dc.identifier.citationMathuru, A.S., Kibat, C., Cheong, W.F., Shui, G., Wenk, M.R., Friedrich, R.W., Jesuthasan, S. (2012-03-20). Chondroitin fragments are odorants that trigger fear behavior in fish. Current Biology 22 (6) : 538-544. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cub.2012.01.061
dc.identifier.issn09609822
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116258
dc.description.abstractThe ability to detect and avoid predators is essential to survival. Various animals, from sea urchins to damselfly larvae, use injury of conspecifics to infer the presence of predators [1-7]. In many fish [1, 8, 9], skin damage causes the release of chemicals that elicit escape and fear in members of the shoal. The chemical nature of the alarm substance ("Schreckstoff" in German) [1], the neural circuits mediating the complex response, and the evolutionary origins of a signal with little obvious benefit to the sender, are unresolved. To address these questions, we use biochemical fractionation to molecularly characterize Schreckstoff. Although hypoxanthine-3 N-oxide has been proposed to be the alarm substance [10, 11], it has not been reliably detected in the skin [12] and there may be other active components [13, 14]. We show that the alarm substance is a mixture that includes the glycosaminoglycan (GAG) chondroitin. Purified chondroitins trigger fear responses. Like skin extract, chondroitins activate the mediodorsal posterior olfactory bulb, a region innervated by crypt neurons [15] that has a unique projection to the habenula [16]. These findings establish GAGs as a new class of odorants in fish, which trigger alarm behavior possibly via a specialized circuit. Video Abstract: © 2012 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cub.2012.01.061
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1016/j.cub.2012.01.061
dc.description.sourcetitleCurrent Biology
dc.description.volume22
dc.description.issue6
dc.description.page538-544
dc.description.codenCUBLE
dc.identifier.isiut000301890900025
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