Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/115907
DC Field | Value | |
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dc.title | Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer. | |
dc.contributor.author | Soong, T.W. | |
dc.contributor.author | Hui, K.M. | |
dc.date.accessioned | 2014-12-12T07:33:59Z | |
dc.date.available | 2014-12-12T07:33:59Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | Soong, T.W., Hui, K.M. (1991). Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer.. Cancer Detection and Prevention 15 (3) : 231-239. ScholarBank@NUS Repository. | |
dc.identifier.issn | 0361090X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/115907 | |
dc.description.abstract | Products encoded by the major histocompatibility complex class I genes are down-regulated in many tumors. The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis. In this report, the expression of HLA genes in human colorectal carcinomas was studied using HLA-A and HLA-B locus-specific probes. Over 50% of the colorectal carcinomas studied showed a reduction in the amount of steady-state HLA mRNA. For some carcinomas, non-coordinated regulation of the HLA-A and HLA-B genes was observed. The HLA expression in some, but not all cases, could be enhanced by gamma-interferon. Over 60% of the colorectal carcinomas also expressed high level of the c-myc oncogene mRNA. However, no correlation could be made between the increase of c-myc expression and the down-regulation of the HLA genes. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.description.sourcetitle | Cancer Detection and Prevention | |
dc.description.volume | 15 | |
dc.description.issue | 3 | |
dc.description.page | 231-239 | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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