Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0092-8674(00)80798-9
DC FieldValue
dc.titlePak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
dc.contributor.authorHing, H.
dc.contributor.authorXiao, J.
dc.contributor.authorHarden, N.
dc.contributor.authorLim, L.
dc.contributor.authorLawrence Zipursky, S.
dc.date.accessioned2014-12-12T07:33:21Z
dc.date.available2014-12-12T07:33:21Z
dc.date.issued1999-06-25
dc.identifier.citationHing, H., Xiao, J., Harden, N., Lim, L., Lawrence Zipursky, S. (1999-06-25). Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97 (7) : 853-863. ScholarBank@NUS Repository. https://doi.org/10.1016/S0092-8674(00)80798-9
dc.identifier.issn00928674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115857
dc.description.abstractThe SH2/SH3 adaptor protein Dock has been proposed to transduce signals from guidance receptors to the actin cytoskeleton in Drosophila photoreceptor (R cell) growth cones. Here, we demonstrate that Drosophila p21-activated kinase (Pak) is required in a Dock pathway regulating R cell axon guidance and targeting. Dock and Pak colocalize to R cell axons and growth cones, physically interact, and their loss-of-function phenotypes are indistinguishable. Normal patterns of R cell connectivity require Pak's kinase activity and binding sites for both Dock and Cdc42/Rac. A membrane- tethered form of Pak (Pak(myr)) acts as a dominant gain-of-function protein. Retinal expression of Pak(myr) rescues the R cell connectivity phenotype in dock mutants. These data establish Pak as a critical regulator of axon guidance and a downstream effector of Dock in vivo.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0092-8674(00)80798-9
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1016/S0092-8674(00)80798-9
dc.description.sourcetitleCell
dc.description.volume97
dc.description.issue7
dc.description.page853-863
dc.description.codenCELLB
dc.identifier.isiut000081162800007
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