Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11517-008-0320-4
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dc.titleNumerical investigation and identification of susceptible sites of atherosclerotic lesion formation in a complete coronary artery bypass model
dc.contributor.authorZhang, J.-M.
dc.contributor.authorChua, L.P.
dc.contributor.authorGhista, D.N.
dc.contributor.authorYu, S.C.M.
dc.contributor.authorTan, Y.S.
dc.date.accessioned2014-12-12T07:33:07Z
dc.date.available2014-12-12T07:33:07Z
dc.date.issued2008-07
dc.identifier.citationZhang, J.-M., Chua, L.P., Ghista, D.N., Yu, S.C.M., Tan, Y.S. (2008-07). Numerical investigation and identification of susceptible sites of atherosclerotic lesion formation in a complete coronary artery bypass model. Medical and Biological Engineering and Computing 46 (7) : 689-699. ScholarBank@NUS Repository. https://doi.org/10.1007/s11517-008-0320-4
dc.identifier.issn01400118
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115839
dc.description.abstractAs hemodynamics is widely believed to correlate with anastomotic stenosis in coronary bypass surgery, this paper investigates the flow characteristics and distributions of the hemodynamic parameters (HPs) in a coronary bypass model (which includes both proximal and distal anastomoses), under physiological flow conditions. Disturbed flows (flow separation/reattachment, vortical and secondary flows) as well as regions of high oscillatory shear index (OSI) with low wall shear stress (WSS), i.e., high-OSI-and-low-WSS and low-OSI-and-high-WSS were found in the proximal and distal anastomoses, especially at the toe and heel regions of distal anastomosis, which indicate highly suspected sites for the onset of the atherosclerotic lesions. The flow patterns found in the graft and distal anastomoses of our model at deceleration phases are different from those of the isolated distal anastomosis model. In addition, a huge significant difference in segmental averages of HPs was found between the distal and proximal anastomoses. These findings further suggest that intimal hyperplasia would be more prone to form in the distal anastomosis than in the proximal anastomosis, particularly along the suture line at the toe and heel of distal anastomosis. © International Federation for Medical and Biological Engineering 2008.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s11517-008-0320-4
dc.sourceScopus
dc.subjectComplete anastomosis
dc.subjectCoronary artery bypass
dc.subjectHemodynamic parameters
dc.subjectNumerical simulation
dc.subjectPulsatile flow
dc.typeArticle
dc.contributor.departmentTEMASEK LABORATORIES
dc.description.doi10.1007/s11517-008-0320-4
dc.description.sourcetitleMedical and Biological Engineering and Computing
dc.description.volume46
dc.description.issue7
dc.description.page689-699
dc.description.codenMBECD
dc.identifier.isiut000256929000007
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