Please use this identifier to cite or link to this item: https://doi.org/10.1016/0925-4773(96)00537-0
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dc.titleMutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila
dc.contributor.authorMurugasu-Oei, B.
dc.contributor.authorBalakrishnan, R.
dc.contributor.authorYang, X.
dc.contributor.authorChia, W.
dc.contributor.authorRodrigues, V.
dc.date.accessioned2014-12-12T07:32:56Z
dc.date.available2014-12-12T07:32:56Z
dc.date.issued1996-06
dc.identifier.citationMurugasu-Oei, B., Balakrishnan, R., Yang, X., Chia, W., Rodrigues, V. (1996-06). Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila. Mechanisms of Development 57 (1) : 91-101. ScholarBank@NUS Repository. https://doi.org/10.1016/0925-4773(96)00537-0
dc.identifier.issn09254773
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115824
dc.description.abstractThe masquerade (mas) locus encodes an extracellular molecule with a striking similarity to serine proteases. The serine residue, which is essential for enzymatic activity, has been substituted by glycine, suggesting that MAS could serve to antagonize serine protease activity. We describe the expression pattern of mas mRNA and protein in the developing embryonic, larval and pupal nervous system and in the epidermis. Total loss of mas function is lethal and results in aberrations in the embryonic central and peripheral nervous systems, consistent with a role in axonal guidance. The possibility that the observed deficits in taste behavior, exhibited by animals with partial loss of mas function, are a result of defects in the adult brain are discussed.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0925-4773(96)00537-0
dc.sourceScopus
dc.subjectAxonal guidance
dc.subjectDrosophila
dc.subjectGustatory pathways
dc.subjectMasquerade
dc.subjectNervous system development
dc.subjectSerine-protease-like
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1016/0925-4773(96)00537-0
dc.description.sourcetitleMechanisms of Development
dc.description.volume57
dc.description.issue1
dc.description.page91-101
dc.description.codenMEDVE
dc.identifier.isiutA1996UW16600008
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