Please use this identifier to cite or link to this item:
https://doi.org/10.1182/blood-2009-12-256149
DC Field | Value | |
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dc.title | Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition | |
dc.contributor.author | Leong, S.M. | |
dc.contributor.author | Tan, B.X. | |
dc.contributor.author | Ahmad, B.B. | |
dc.contributor.author | Yan, T. | |
dc.contributor.author | Chee, L.Y. | |
dc.contributor.author | Ang, S.T. | |
dc.contributor.author | Tay, K.G. | |
dc.contributor.author | Koh, L.P. | |
dc.contributor.author | Yeoh, A.E.J. | |
dc.contributor.author | Koay, E.S.-C. | |
dc.contributor.author | Mok, Y.-K. | |
dc.contributor.author | Lim, T.M. | |
dc.date.accessioned | 2014-12-12T07:32:55Z | |
dc.date.available | 2014-12-12T07:32:55Z | |
dc.date.issued | 2010-10-28 | |
dc.identifier.citation | Leong, S.M., Tan, B.X., Ahmad, B.B., Yan, T., Chee, L.Y., Ang, S.T., Tay, K.G., Koh, L.P., Yeoh, A.E.J., Koay, E.S.-C., Mok, Y.-K., Lim, T.M. (2010-10-28). Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition. Blood 116 (17) : 3286-3296. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2009-12-256149 | |
dc.identifier.issn | 00064971 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/115823 | |
dc.description.abstract | In up to one-third of patients with acute myeloid leukemia, a C-terminal frame-shift mutation results in abnormal and abundant cytoplasmic accumulation of the usually nucleoli-bound protein nucleophosmin (NPM), and this is thought to function in cancer pathogenesis. Here, we demonstrate a gain-of-function role for cytoplasmic NPM in the inhibition of caspase signaling. The NPM mutant specifically inhibits the activities of the cell-death proteases, caspase-6 and -8, through direct interaction with their cleaved, active forms, but not the immature procaspases. The cytoplasmic NPM mutant not only affords protection from death ligand-induced cell death but also suppresses caspase-6/-8-mediated myeloid differentiation. Our data hence provide a potential explanation for the myeloid-specific involvement of cytoplasmic NPM in the leukemogenesis of a large subset of acute myeloid leukemia. © 2010 by The American Society of Hematology. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1182/blood-2009-12-256149 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.1182/blood-2009-12-256149 | |
dc.description.sourcetitle | Blood | |
dc.description.volume | 116 | |
dc.description.issue | 17 | |
dc.description.page | 3286-3296 | |
dc.description.coden | BLOOA | |
dc.identifier.isiut | 000283583700024 | |
Appears in Collections: | Staff Publications |
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