Please use this identifier to cite or link to this item: https://doi.org/10.1158/1055-9965.EPI-05-0153
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dc.titleEvidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development
dc.contributor.authorSiddique, M.M.
dc.contributor.authorBalram, C.
dc.contributor.authorFiszer-Maliszewska, L.
dc.contributor.authorAggarwal, A.
dc.contributor.authorTan, A.
dc.contributor.authorTan, P.
dc.contributor.authorSoo, K.C.
dc.contributor.authorSabapathy, K.
dc.date.accessioned2014-12-12T07:31:31Z
dc.date.available2014-12-12T07:31:31Z
dc.date.issued2005-09
dc.identifier.citationSiddique, M.M., Balram, C., Fiszer-Maliszewska, L., Aggarwal, A., Tan, A., Tan, P., Soo, K.C., Sabapathy, K. (2005-09). Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development. Cancer Epidemiology Biomarkers and Prevention 14 (9) : 2245-2252. ScholarBank@NUS Repository. https://doi.org/10.1158/1055-9965.EPI-05-0153
dc.identifier.issn10559965
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115710
dc.description.abstractPolymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Asians were found to preferentially express the pro allele whereas the Caucasians preferentially express the arg allele. On the contrary, about 75% of the heterozygote Chinese breast cancer patients preferentially expressed the arg allele, which rarely contained any somatic mutations. Moreover, histologically normal tissues from Chinese heterozygote breast cancer patients showed selective expression of the arg allele, in contrast to the preferential expression of the pro allele in heterozygote healthy normal breast tissues. Together, the data suggest that the expression of the different p53 polymorphs is selectively regulated in different ethnic populations, and that the arg allele is activated during cancer development in Asians. Thus, the expression status of the p53 polymorphs, rather than the genotypic status, might be a useful indicator for cancer susceptibility. Copyright © 2005 American Association for Cancer Research.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1158/1055-9965.EPI-05-0153
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1158/1055-9965.EPI-05-0153
dc.description.sourcetitleCancer Epidemiology Biomarkers and Prevention
dc.description.volume14
dc.description.issue9
dc.description.page2245-2252
dc.description.codenCEBPE
dc.identifier.isiut000231971400030
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