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|Title:||A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum||Authors:||Dong, H.
|Issue Date:||Jul-2000||Citation:||Dong, H.,Gou, Y.-L.,Kini, R.M.,Xu, H.-X.,Chen, S.-X.,Teo, S.L.M.,But, P.P.-H. (2000-07). A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum. Chemical and Pharmaceutical Bulletin 48 (7) : 1087-1089. ScholarBank@NUS Repository.||Abstract:||A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest- 16(17)-E-en-3β,5α,6β,20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 μg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.||Source Title:||Chemical and Pharmaceutical Bulletin||URI:||http://scholarbank.nus.edu.sg/handle/10635/115562||ISSN:||00092363|
|Appears in Collections:||Staff Publications|
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