Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/115562
| Title: | A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum | Authors: | Dong, H. Gou, Y.-L. Kini, R.M. Xu, H.-X. Chen, S.-X. Teo, S.L.M. But, P.P.-H. |
Keywords: | Polyhydroxysterol Sarcophyton trocheliophorum Soft coral |
Issue Date: | Jul-2000 | Citation: | Dong, H.,Gou, Y.-L.,Kini, R.M.,Xu, H.-X.,Chen, S.-X.,Teo, S.L.M.,But, P.P.-H. (2000-07). A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum. Chemical and Pharmaceutical Bulletin 48 (7) : 1087-1089. ScholarBank@NUS Repository. | Abstract: | A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest- 16(17)-E-en-3β,5α,6β,20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 μg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes. | Source Title: | Chemical and Pharmaceutical Bulletin | URI: | http://scholarbank.nus.edu.sg/handle/10635/115562 | ISSN: | 00092363 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.