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Title: A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum
Authors: Dong, H. 
Gou, Y.-L. 
Kini, R.M. 
Xu, H.-X.
Chen, S.-X.
Teo, S.L.M. 
But, P.P.-H.
Keywords: Polyhydroxysterol
Sarcophyton trocheliophorum
Soft coral
Issue Date: Jul-2000
Citation: Dong, H.,Gou, Y.-L.,Kini, R.M.,Xu, H.-X.,Chen, S.-X.,Teo, S.L.M.,But, P.P.-H. (2000-07). A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum. Chemical and Pharmaceutical Bulletin 48 (7) : 1087-1089. ScholarBank@NUS Repository.
Abstract: A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest- 16(17)-E-en-3β,5α,6β,20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 μg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.
Source Title: Chemical and Pharmaceutical Bulletin
ISSN: 00092363
Appears in Collections:Staff Publications

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