Please use this identifier to cite or link to this item:
https://doi.org/10.5858/arpa.2011-0430-OA
DC Field | Value | |
---|---|---|
dc.title | Lymphocytic follicles and aggregates are a determinant of mucosal damage and duration of diarrhea | |
dc.contributor.author | Shah, N. | |
dc.contributor.author | Thakkar, B. | |
dc.contributor.author | Shen, E. | |
dc.contributor.author | Loh, M. | |
dc.contributor.author | Chong, P.Y. | |
dc.contributor.author | Gan, W.H. | |
dc.contributor.author | Tu, T.M. | |
dc.contributor.author | Shen, L. | |
dc.contributor.author | Soong, R. | |
dc.contributor.author | Salto-Tellez, M. | |
dc.date.accessioned | 2014-12-12T07:12:06Z | |
dc.date.available | 2014-12-12T07:12:06Z | |
dc.date.issued | 2013-01 | |
dc.identifier.citation | Shah, N., Thakkar, B., Shen, E., Loh, M., Chong, P.Y., Gan, W.H., Tu, T.M., Shen, L., Soong, R., Salto-Tellez, M. (2013-01). Lymphocytic follicles and aggregates are a determinant of mucosal damage and duration of diarrhea. Archives of Pathology and Laboratory Medicine 137 (1) : 83-89. ScholarBank@NUS Repository. https://doi.org/10.5858/arpa.2011-0430-OA | |
dc.identifier.issn | 00039985 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/115176 | |
dc.description.abstract | Context.-Nonspecific changes (nonspecific chronic inflammation) in patients with chronic diarrhea represent the commonest diagnosis in colorectal biopsy interpretation, but these changes are of little clinical significance. Objective.-To find, within this group, histologic and immunohistologic diagnostic criteria to predict the duration and resolution of diarrhea. Design.-Detailed clinical features and histologic findings were analyzed in a cohort of 47 patients with chronic diarrhea, with near-normal histology and no clear-cut known etiologic agent. Immunohistochemistry to mast cells (CD117) and Treg cells (FOXP3) was also assessed in 39 patients. Results.-Increased number of lymphoid follicles and aggregates, increased number of mast cells, and paucity of Treg were the statistically significant key findings (P = .003, P = .008, and P = .04, respectively). The duration of diarrhea was correlated with the number of large lymphoid follicles and aggregates (P = .001, r = .48), number of total lymphoid follicles and aggregates (P = .003, r = .43), density of lymphoid follicles and aggregates (P = .009, r = .38), and total lymphoid follicles and aggregates per biopsy (P = .004, r = .42) and the number of mast cells (P = .001, r = .52). The number of mast cells and Treg cells showed significant difference between resolved and unresolved cases (P = .001 and P = .01 respectively). Conclusions.-Lymphocytic follicles and aggregates colitis, previously regarded as of negligible diagnostic significance, allows the prediction of the behavior of chronic diarrhea in a subset of patients with nonspecific changes on colonic biopsy. The increased number of mast cells and paucity of Treg cells further helps to identify such unresolved cases. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.5858/arpa.2011-0430-OA | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.5858/arpa.2011-0430-OA | |
dc.description.sourcetitle | Archives of Pathology and Laboratory Medicine | |
dc.description.volume | 137 | |
dc.description.issue | 1 | |
dc.description.page | 83-89 | |
dc.description.coden | ARPAA | |
dc.identifier.isiut | 000313625100014 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.