Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.eplepsyres.2009.10.015
Title: Cyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy
Authors: Tang, F.R. 
Loke, W.K.
Keywords: Epileptogenesis
Structural changes
Temporal lobe epilepsy
Issue Date: Mar-2010
Citation: Tang, F.R., Loke, W.K. (2010-03). Cyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy. Epilepsy Research 89 (1) : 43-51. ScholarBank@NUS Repository. https://doi.org/10.1016/j.eplepsyres.2009.10.015
Abstract: While different hypotheses have been proposed to explain the mechanism of onset of temporal lobe epilepsy (TLE), most of them are based on structural, electrophysiological, cellular or molecular changes in one particular area. Extensive neuronal loss, axon reorganization, dendrite and dendritic spine growth make it impossible to apply one hypothesis to explain epileptogenesis for patients or animal models with different pathophysiological changes in the brain. It is therefore hypothesized that cyto-, axo- and dendro-architectonic changes at multiple brain regions may be involved in epileptogenesis in TLE. In the review, structural changes of the limbic system, in particular, hippocampus, entorhinal cortex, subiculum and amygdale, in the mouse pilocarpine model of TLE will be summarized. Their functional significance will be discussed. The final conclusion and future research directions will then be made. © 2009 Elsevier B.V.
Source Title: Epilepsy Research
URI: http://scholarbank.nus.edu.sg/handle/10635/115053
ISSN: 09201211
DOI: 10.1016/j.eplepsyres.2009.10.015
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