Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0304-3835(00)00391-8
DC Field | Value | |
---|---|---|
dc.title | Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells | |
dc.contributor.author | Liu, J. | |
dc.contributor.author | Shen, H.-M. | |
dc.contributor.author | Ong, C.-N. | |
dc.date.accessioned | 2014-12-01T06:56:46Z | |
dc.date.available | 2014-12-01T06:56:46Z | |
dc.date.issued | 2000-05-29 | |
dc.identifier.citation | Liu, J., Shen, H.-M., Ong, C.-N. (2000-05-29). Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells. Cancer Letters 153 (1-2) : 85-93. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(00)00391-8 | |
dc.identifier.issn | 03043835 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/113638 | |
dc.description.abstract | Salvia miltiorrhiza (SM) is a traditional Chinese herbal medicine, commonly used to treat liver diseases in China for centuries. Several earlier studies have indicated that SM exhibits anti-tumor properties, but its mechanism remains to be elucidated. In this study, we evaluated the molecular mechanism of SM in a human hepatoma cell line, HepG2. Our results show that SM exerted clear cytotoxic effects, and strongly inhibited the proliferation of HepG2 cells. It was also observed that SM treatment caused apoptotic cell death as evaluated by: (a), morphological changes by using acridine orange/ethidium bromide staining; (b), DNA fragmentation by TdT-mediated dUTP nick end labeling (TUNEL); and (c), sub-G1 cell analysis. Furthermore, depletion of intracellular glutathione (GSH) and reduction of mitochondrial membrane potential were found to be involved in the initiation of apoptosis by SM. Copyright (C) 2000 Elsevier Science Ireland Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(00)00391-8 | |
dc.source | Scopus | |
dc.subject | Glutathione | |
dc.subject | Herbal medicine | |
dc.subject | Mitochondrial membrane potential | |
dc.subject | Proliferation | |
dc.subject | Sub-G1 cell | |
dc.subject | TdT-mediated dUTP nick end labeling | |
dc.type | Article | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.description.doi | 10.1016/S0304-3835(00)00391-8 | |
dc.description.sourcetitle | Cancer Letters | |
dc.description.volume | 153 | |
dc.description.issue | 1-2 | |
dc.description.page | 85-93 | |
dc.description.coden | CALED | |
dc.identifier.isiut | 000166661600013 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.