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|Title:||Distinct regions of periaqueductal gray (PAG) are involved in freezing behavior in hooded PVG rats on the cat-freezing test apparatus||Authors:||Farook, J.M.
|Issue Date:||9-Jan-2004||Citation:||Farook, J.M., Wang, Q., Moochhala, S.M., Zhu, Z.Y., Lee, L., Wong, P.T.-H. (2004-01-09). Distinct regions of periaqueductal gray (PAG) are involved in freezing behavior in hooded PVG rats on the cat-freezing test apparatus. Neuroscience Letters 354 (2) : 139-142. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2003.10.011||Abstract:||The periaqueductal gray (PAG) is considered to be an exit relay for defensive responses. Studies have shown that the ventrolateral periaqueductal gray (vlPAG) plays a role in the expression of freezing behavior whereas dorsolateral periaqueductal gray (dlPAG) is involved on both freezing and active forms of defensive behaviors. To further elucidate this theory, lesioned vlPAG and dlPAG rats were exposed to a cat in the cat-freezing test apparatus. Subsequently, a 7-day repeated exposure to a cat was done on the vlPAG and dlPAG lesioned rats. Results showed that the vlPAG lesioned rats demonstrated significant decrease in freezing behavior and corresponding increase in locomotor activity, while the dlPAG lesioned rats failed to show any significance. Subsequent repeated exposure of the vlPAG lesioned rats to a cat for 7 days showed a gradual decrease in freezing behavior with significance shown at days 5, 6 and 7 while the dlPAG lesioned rats failed to show any changes. These results suggest that vlPAG regulates freezing behavior in hooded PVG rats. © 2003 Elsevier Ireland Ltd. All rights reserved.||Source Title:||Neuroscience Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/113444||ISSN:||03043940||DOI:||10.1016/j.neulet.2003.10.011|
|Appears in Collections:||Staff Publications|
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