Please use this identifier to cite or link to this item: https://doi.org/10.1002/(SICI)1097-0320(19960315)26:13.0.CO;2-E
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dc.titleAge- and Sex-Related changes in lymphocyte subpopulations of healthy Asian subjects: From birth to adulthood
dc.contributor.authorLee, B.-W.
dc.contributor.authorYap, H.-K.
dc.contributor.authorChew, F.-T.
dc.contributor.authorQuah, T.-C.
dc.contributor.authorPrabhakaran, K.
dc.contributor.authorChan, G.S.H.
dc.contributor.authorWong, S.-C.
dc.contributor.authorSeah, C.-C.
dc.date.accessioned2014-12-01T06:53:30Z
dc.date.available2014-12-01T06:53:30Z
dc.date.issued1996-03-15
dc.identifier.citationLee, B.-W.,Yap, H.-K.,Chew, F.-T.,Quah, T.-C.,Prabhakaran, K.,Chan, G.S.H.,Wong, S.-C.,Seah, C.-C. (1996-03-15). Age- and Sex-Related changes in lymphocyte subpopulations of healthy Asian subjects: From birth to adulthood. Communications in Clinical Cytometry 26 (1) : 8-15. ScholarBank@NUS Repository. <a href="https://doi.org/10.1002/(SICI)1097-0320(19960315)26:13.0.CO;2-E" target="_blank">https://doi.org/10.1002/(SICI)1097-0320(19960315)26:13.0.CO;2-E</a>
dc.identifier.issn01964763
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113351
dc.description.abstractFlow cytometric analysis of lymphocyte subsets were evaluated in 391 healthy Asian subjects ranging in age from birth to 40 years. Lymphocyte subsets were analysed using specific monoclonal antibodies: CD20 (B cells), CD3 and CD2 (T cells), 0016 and CD56+ (NK cells), CD4/CD3+ (helper-inducer T cells), CD8/CD3+ (suppressor/cytotoxic T cells), HLA-DR expression on CD3 and CD25 (Tac) on CD3. The total white cell count, absolute lymphocyte counts, and B cell percentages peaked in infancy and declined steadily with age. Absolute counts of each subset, which were derived from absolute lymphocyte counts, also followed this trend. Increases with age were seen in the NK, T cell (CD2, CD3), and CD8 percentages. Males tended to have higher NK and CD8 percentages than females, and, conversely, females had higher CD3 and CD4 percentages than males. Comparison of our results with studies involving Caucasian subjects indicated higher NK percentages in our Asian population and lower CD4 absolute counts in the males of our population. These results indicate the presence of age, sex, and probable racial differences in lymphocyte subset expression. Our results may serve as reference standards for the Asian population.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/(SICI)1097-0320(19960315)26:13.0.CO;2-E
dc.sourceScopus
dc.subjectAsians
dc.subjectChildren
dc.subjectLymphocyte immunophenotyping
dc.subjectReference range
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1002/(SICI)1097-0320(19960315)26:13.0.CO;2-E
dc.description.sourcetitleCommunications in Clinical Cytometry
dc.description.volume26
dc.description.issue1
dc.description.page8-15
dc.description.codenCCCYE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

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