Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112815
Title: The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives
Authors: Sng, J.-H. 
Chang, J.
Feroze, F. 
Rahman, N.
Tan, W.
Lim, S.
Lehnert, M.
Van Der Pool, S.
Wong, J.
Keywords: BRCA1
Breast cancer
Chinese
Issue Date: 2000
Citation: Sng, J.-H., Chang, J., Feroze, F., Rahman, N., Tan, W., Lim, S., Lehnert, M., Van Der Pool, S., Wong, J. (2000). The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives. British Journal of Cancer 82 (3) : 538-542. ScholarBank@NUS Repository.
Abstract: The purpose of this study was to determine the prevalence of BRCA1 mutations in Chinese breast cancer patients in Singapore. BRCA1 analysis was conducted in consecutive patients with breast cancer before the age of 40 years (76 women), or whose relatives had breast or ovarian cancer (16 women). Ten patients had both early onset breast cancer and affected relatives. Genomic DNA from peripheral mononuclear blood cells was studied by using the protein transcription-translation assay (exon 11) and single-strand conformational polymorphism, with subsequent DNA sequencing. All six disease-causing mutations occurred in women under 40 years (8.6%) with three occurring in patients under 35 years (three out of 22 patients, 13.6%). Mis-sense mutations of unknown significance were found in three patients. Two of the ten women with affected relatives under 40 years had BRCA1 mutations. The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer is similar to that observed in Caucasian women. Most Chinese patients with affected relatives were not carriers of BRCA1 mutations. (C) 2000 Cancer Research Campaign.
Source Title: British Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/112815
ISSN: 00070920
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

68
checked on Jan 18, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.