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|Title:||The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1||Authors:||Leung, T.K.C.
|Issue Date:||Jan-1992||Citation:||Leung, T.K.C.,Hall, C.,Rajendran, M.,Spurr, N.K.,Lim, L. (1992-01). The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. Genomics 12 (1) : 74-79. ScholarBank@NUS Repository.||Abstract:||HSPA6 is a member of the human heat-shock protein gene family, encoding a basic 70-kDa protein, with unique induction characteristics (Leung et al., 1990, Biochem. J. 267: 125-132). Hybridization analyses with a somatic cell hybrid DNA panel localized the gene to chromosome 1q. The highly related HSPA7 DNA sequence (Voellmy et al., 1985, Proc. Natl. Acad. Sci. USA 82: 4949-4953) colocalized. Both HSPA6 and HSPA7 represent functional genes, as determined by analyses of mRNA from heat-shocked human cells using specific oligonucleotides, although their pattern of expression differed. Neither mRNA was detected in the absence of heat stress. A BamHI polymorphism in the HSPA7 gene was present in a predominantly Asian population. © 1992.||Source Title:||Genomics||URI:||http://scholarbank.nus.edu.sg/handle/10635/112114||ISSN:||08887543|
|Appears in Collections:||Staff Publications|
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