Please use this identifier to cite or link to this item: https://doi.org/10.1038/8070
Title: Splicing of α(1A) subunit gene generates phenotypic variants of P- and Q-type calcium channels
Authors: Bourinet, E.
Soong, T.W. 
Sutton, K.
Slaymaker, S.
Mathews, E.
Monteil, A.
Zamponi, G.W.
Nargeot, J.
Snutch, T.P.
Issue Date: May-1999
Citation: Bourinet, E., Soong, T.W., Sutton, K., Slaymaker, S., Mathews, E., Monteil, A., Zamponi, G.W., Nargeot, J., Snutch, T.P. (1999-05). Splicing of α(1A) subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nature Neuroscience 2 (5) : 407-415. ScholarBank@NUS Repository. https://doi.org/10.1038/8070
Abstract: P-type and Q-type calcium channels mediate neurotransmitter release at many synapses in the mammalian nervous system. The α(1A) calcium channel has been implicated in the etiologies of conditions such as episodic ataxia, epilepsy and familial migraine, and shares several properties with native P- and Q-type channels. However, the exact relationship between α(1A) and P- and Q-type channels is unknown. Here we report that alternative splicing of the α(1A) subunit gene results in channels with distinct kinetic, pharmacological and modulatory properties. Overall, the results indicate that alternative splicing of the α(1A) gene generates P-type and Q-type channels as well as multiple phenotypic variants.
Source Title: Nature Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/112084
ISSN: 10976256
DOI: 10.1038/8070
Appears in Collections:Staff Publications

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