Please use this identifier to cite or link to this item:
Title: Response of a murine Vβ18-alloreactive CTL clone to bacterial superantigens
Authors: Hwang, L.-A. 
Sabapathy, T.K. 
Hui, K.M. 
Issue Date: 1995
Citation: Hwang, L.-A., Sabapathy, T.K., Hui, K.M. (1995). Response of a murine Vβ18-alloreactive CTL clone to bacterial superantigens. Cellular Immunology 163 (1) : 96-105. ScholarBank@NUS Repository.
Abstract: We have isolated, by limiting dilution, a murine antiH-2Kb T cell line derived from AKR/J mouse spleen cells following stimulation with H-2Kb+ cells. This clone, designated 2AH10, has the phenotype H-2K(k+), CD8+, LFA-1+, ICAM-1+, and IL-2R+ and, as determined by DNA-sequencing reactions, expresses the Vβ18 T cell receptor gene segment. Clone 2AH10 specifically lysed H-2Kb+ target cells and on stimulation with H-2K(b+) cells proliferated to secrete IFN-γ, LT, and GM-CSF. Clone 2AH10 was responsive to the bacterial superantigens SEC1 and TSST-1 when stimulated in the context of murine MHC class II+ cells. In addition to SEC1 and TSST-1, when human MHC class II+ cells were employed, clone 2AH10 responded to a wider range of bacterial superantigens including SEE, SED, and SEE.
Source Title: Cellular Immunology
ISSN: 00088749
DOI: 10.1006/cimm.1995.1103
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Feb 1, 2023


checked on Feb 1, 2023

Page view(s)

checked on Jan 26, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.