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Title: Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins
Authors: Lim, L.
Hall, C.
Monfries, C. 
Keywords: Actin morphology
Rho GTPases
Issue Date: Oct-1996
Citation: Lim, L., Hall, C., Monfries, C. (1996-10). Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins. Seminars in Cell and Developmental Biology 7 (5) : 699-706. ScholarBank@NUS Repository.
Abstract: Cdc42, Rac and Rho GTPase each regulates distinct morphological changes in response to specific growth factors. These changes which involve actin-containing cytoskeletal structures may underlie aspects of growth and development. Proteins binding to the active GTP-bound form of the GTPase including the Cdc42/ Rac activated PAK, and the Rho associated kinase ROK can act as morphological effectors as can the RacGAP chimaerin. In fibroblasts and neuronal-type cells, the growth factors evoke morphological changes by activating individual GTPase pathways or Rac-Rho and Cdc42-Rac hierarchical pathways. There is also evidence for Cdc42-Rho antagonism. The morphological outcome will depend on the level of activation of the different GT Pases by their stimulatory growth factor.
Source Title: Seminars in Cell and Developmental Biology
ISSN: 10849521
DOI: 10.1006/scdb.1996.0086
Appears in Collections:Staff Publications

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