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|Title:||Promotion of tumor growth by transfecting antisense DNA to suppress endogenous H-2Kk MHC gene expression in AKR mouse thymoma||Authors:||Hui, K.M.
|Issue Date:||Aug-1991||Citation:||Hui, K.M.,Sim, B.C.,Foo, T.T.,Oei, A.A. (1991-08). Promotion of tumor growth by transfecting antisense DNA to suppress endogenous H-2Kk MHC gene expression in AKR mouse thymoma. Cellular Immunology 136 (1) : 80-94. ScholarBank@NUS Repository.||Abstract:||Many AKR spontaneous thymomas are reported to express different amounts of the major histocompatibility complex class I H-2Kk molecules. Moreover, H-2Kk-deficient AKR tumor cells are found to be more malignant when compared to tumor cells that express abundant levels of the H-2Kk molecules. To corroborate further the role of H-2Kk in tumorigenesis of AKR leukemia, we have, in this study, expressed antisense H-2Kk RNA in a high-H-2Kk-expressing and poorly tumorigenic AKR thymoma cell line 369. The down-regulation of H-2Kk molecules in the transfected 369 clones rendered them more tumorigenic in syngeneic AKR/J mice. The increase in oncogenicity correlates well with a concomitant reduction in their susceptibility to tumor-specific cytotoxic T lymphocytes in vitro. These results suggest the relevance of H-2Kk molecules in the immune surveillance of AKR tumors. © 1991.||Source Title:||Cellular Immunology||URI:||http://scholarbank.nus.edu.sg/handle/10635/112026||ISSN:||00088749|
|Appears in Collections:||Staff Publications|
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