Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-1119(96)00414-3
Title: Isolation of the gene coding for caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein
Authors: Chen, W. 
Yap, S.F. 
Lim, L.
Keywords: DNA sequencing
Exon
Nematode
Rho subfamily
Sequence alignment
Issue Date: 21-Nov-1996
Citation: Chen, W., Yap, S.F., Lim, L. (1996-11-21). Isolation of the gene coding for caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein. Gene 180 (1-2) : 217-219. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1119(96)00414-3
Abstract: When screening a Caenorhabditis elegans genomic library using the human Rac1 cDNA as probe, a hybridizing fragment of 2.7 kb was isolated which contained four exons with high sequence similarity to CeRac1, coding for the nematode homologue of the Ras-related small GTP-binding protein Rac1. The putative translational product of 195 amino acids (aa) from the exons displayed 88% identity to the sequence of CeRac1. Interestingly, three alterations were found in the N-terminal 'effector domain' (residues 22-45) which hitherto was identical among all known Rac p21s, suggesting that CeRac2 might have different targets/functions for nematode development. Additionally, an insertion of 4 aa was found in the hypervariable region at the C terminus of CeRac2.
Source Title: Gene
URI: http://scholarbank.nus.edu.sg/handle/10635/111953
ISSN: 03781119
DOI: 10.1016/S0378-1119(96)00414-3
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