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https://doi.org/10.1016/S0378-1119(96)00414-3
Title: | Isolation of the gene coding for caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein | Authors: | Chen, W. Yap, S.F. Lim, L. |
Keywords: | DNA sequencing Exon Nematode Rho subfamily Sequence alignment |
Issue Date: | 21-Nov-1996 | Citation: | Chen, W., Yap, S.F., Lim, L. (1996-11-21). Isolation of the gene coding for caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein. Gene 180 (1-2) : 217-219. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1119(96)00414-3 | Abstract: | When screening a Caenorhabditis elegans genomic library using the human Rac1 cDNA as probe, a hybridizing fragment of 2.7 kb was isolated which contained four exons with high sequence similarity to CeRac1, coding for the nematode homologue of the Ras-related small GTP-binding protein Rac1. The putative translational product of 195 amino acids (aa) from the exons displayed 88% identity to the sequence of CeRac1. Interestingly, three alterations were found in the N-terminal 'effector domain' (residues 22-45) which hitherto was identical among all known Rac p21s, suggesting that CeRac2 might have different targets/functions for nematode development. Additionally, an insertion of 4 aa was found in the hypervariable region at the C terminus of CeRac2. | Source Title: | Gene | URI: | http://scholarbank.nus.edu.sg/handle/10635/111953 | ISSN: | 03781119 | DOI: | 10.1016/S0378-1119(96)00414-3 |
Appears in Collections: | Staff Publications |
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