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dc.titleinscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
dc.contributor.authorCarmena, A.
dc.contributor.authorMurugasu-Oei, B.
dc.contributor.authorMenon, D.
dc.contributor.authorJiménez, F.
dc.contributor.authorChia, W.
dc.identifier.citationCarmena, A.,Murugasu-Oei, B.,Menon, D.,Jiménez, F.,Chia, W. (1998-02-01). inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. Genes and Development 12 (3) : 304-315. ScholarBank@NUS Repository.
dc.description.abstractEach larval hemisegment comprises ~30 uniquely specified somatic muscles. These derive from muscle founders that arise as distinct sibling pairs from the division of muscle progenitor cells. We have analyzed the progenitor cell divisions of three mesodermal lineages that generate muscle (and pericardial cell) founders. Our results show that Inscuteable and Numb proteins are localized as cortical crescents on opposite sides of dividing progenitor cells. Asymmetric segregation of Numb into one of the sibling myoblasts depends on inscuteable and is essential for the specification of distinct sibling cell fates. Loss of numb or inscuteable results in opposite cell fate transformations-both prevent sibling myoblasts from adopting distinct identities, resulting in duplicated or deleted mesodermal structures. Our results indicate that the muscle progenitor cell divisions are intrinsically asymmetric; moreover, the involvement of both inscuteable and numb/N suggests that the specification of the distinct cell fates of sibling myoblasts requires intrinsic and extrinsic cues.
dc.subjectAsymmetric cell division
dc.subjectMuscle progenitor
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.description.sourcetitleGenes and Development
Appears in Collections:Staff Publications

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