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Title: HLA genotyping of colorectal carcinoma in the Chinese population
Authors: Bidwell, J.L.
Soong, T.W.
Raymond, P.A.
Doherty, D.G.
Hui, K.M. 
Issue Date: May-1992
Citation: Bidwell, J.L.,Soong, T.W.,Raymond, P.A.,Doherty, D.G.,Hui, K.M. (1992-05). HLA genotyping of colorectal carcinoma in the Chinese population. Human Immunology 34 (1) : 19-23. ScholarBank@NUS Repository.
Abstract: The HLA-DR genotypes of 61 primary colorectal carcinomas obtained from patients of Chinese origin were determined by using DNA-RFLP. No increase or decrease of a particular HLA genotype could be ascertained with the disease, although we detected an antigen frequency of 29.5% for the serologically ill-defined DR"X3" specificity. We identified and sequenced HLA-DRB1 and DRB3 genes from the DR"X3" haplotype. The DR"X3" DRB1 gene was found to be identical to DRB1*1201 (Dr5{w12}). A unique observation is its unusual linkage with DRB3*0101 (DRw52a) or DRB3*0301 (DRw52c) instead of the usual linkage with DRB3*0201/2 (DRw52b). These associations are rare in whites and blacks. © 1992.
Source Title: Human Immunology
ISSN: 01988859
Appears in Collections:Staff Publications

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