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https://scholarbank.nus.edu.sg/handle/10635/111869
DC Field | Value | |
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dc.title | Efficient synthesis of mosquitocidal toxins in Asticcacaulis excentricus demonstrates potential of gram-negative bacteria in mosquito control | |
dc.contributor.author | Liu, J.-W. | |
dc.contributor.author | Yap, W.H. | |
dc.contributor.author | Thanabalu, T. | |
dc.contributor.author | Porter, A.G. | |
dc.date.accessioned | 2014-11-28T02:50:35Z | |
dc.date.available | 2014-11-28T02:50:35Z | |
dc.date.issued | 1996 | |
dc.identifier.citation | Liu, J.-W.,Yap, W.H.,Thanabalu, T.,Porter, A.G. (1996). Efficient synthesis of mosquitocidal toxins in Asticcacaulis excentricus demonstrates potential of gram-negative bacteria in mosquito control. Nature Biotechnology 14 (3) : 343-347. ScholarBank@NUS Repository. | |
dc.identifier.issn | 0733222X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/111869 | |
dc.description.abstract | The control of mosquitoes with chemical insecticides pollutes the environment and leads to resistance in mosquito populations. Bacterial control of mosquito larvae with Bacillus sphaericus and Bacillus thuringiensis subsp. israelensis, which produce protein toxins, has proved useful, safe, and nonpolluting. These bacteria do, however, suffer from disadvantages, including rapid settling, UV sensitivity, and lack of persistance of spores, proteolysis of toxins, narrow host range, and high production costs. Here we show that the Gram-negative bacterium Asticcacaulis excentricus is a promising host for delivering toxins to mosquito larvae. Plasmid-transformed A. excentricus cells expressing the binary toxin of B. sphaericus exhibited toxicity to Culex and Anopheles mosquito larvae similar to that of the high-toxicity strains of B. sphaericus which produce several toxins. A. excentricus has potential advantages as a larvicide compared with the bacilli, especially persistance in the larval feeding zone, resistance to UV light, lack of toxin-degrading proteases, and low production costs. | |
dc.source | Scopus | |
dc.subject | Asticcacaulis excentricus | |
dc.subject | insecticide | |
dc.type | Article | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.contributor.department | INSTITUTE OF MOLECULAR AGROBIOLOGY | |
dc.description.sourcetitle | Nature Biotechnology | |
dc.description.volume | 14 | |
dc.description.issue | 3 | |
dc.description.page | 343-347 | |
dc.description.coden | NABIF | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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