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|Title:||A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library||Authors:||Yao, Z.-J.
Random peptide library
|Issue Date:||15-Mar-1995||Citation:||Yao, Z.-J.,Kao, M.C.C.,Loh, K.-C.,Chung, M.C.M. (1995-03-15). A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library. FEMS Microbiology Letters 127 (1-2) : 93-98. ScholarBank@NUS Repository.||Abstract:||From a panel of monoclonal antibodies of dengue viruses, a serotype-specific epitope of dengue virus 1 was screened from a random peptide library displayed on phage. The epitope was the determinant reactive with monoclonal antibody 15F3-1 that was specific to dengue 1. The screening was monitored by a dot blotting procedure, and after three rounds of screening a consensus motif, HRYSWK, was found. This sequence matches the sequence HKYSWK, corresponding to the amino acid residues 885-890 of polyprotein or residues 111-116 of the non-structural protein 1 of dengue virus serotype 1. The linear epitope was confirmed by testing the antigenicity of chemically synthesized 8-branched peptide. © 1995.||Source Title:||FEMS Microbiology Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/111032||ISSN:||03781097|
|Appears in Collections:||Staff Publications|
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