Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/111032
Title: A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library
Authors: Yao, Z.-J. 
Kao, M.C.C. 
Loh, K.-C. 
Chung, M.C.M.
Keywords: Dengue
Epitope
Random peptide library
Issue Date: 15-Mar-1995
Citation: Yao, Z.-J.,Kao, M.C.C.,Loh, K.-C.,Chung, M.C.M. (1995-03-15). A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library. FEMS Microbiology Letters 127 (1-2) : 93-98. ScholarBank@NUS Repository.
Abstract: From a panel of monoclonal antibodies of dengue viruses, a serotype-specific epitope of dengue virus 1 was screened from a random peptide library displayed on phage. The epitope was the determinant reactive with monoclonal antibody 15F3-1 that was specific to dengue 1. The screening was monitored by a dot blotting procedure, and after three rounds of screening a consensus motif, HRYSWK, was found. This sequence matches the sequence HKYSWK, corresponding to the amino acid residues 885-890 of polyprotein or residues 111-116 of the non-structural protein 1 of dengue virus serotype 1. The linear epitope was confirmed by testing the antigenicity of chemically synthesized 8-branched peptide. © 1995.
Source Title: FEMS Microbiology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/111032
ISSN: 03781097
Appears in Collections:Staff Publications

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