Please use this identifier to cite or link to this item: https://doi.org/10.1021/ac0204909
Title: Application of cyclam-capped β-cyclodextrin-bonded silica particles as a chiral stationary phase in capillary electrochromatography for enantiomeric separations
Authors: Gong, Y. 
Lee, H.K. 
Issue Date: 15-Mar-2003
Citation: Gong, Y., Lee, H.K. (2003-03-15). Application of cyclam-capped β-cyclodextrin-bonded silica particles as a chiral stationary phase in capillary electrochromatography for enantiomeric separations. Analytical Chemistry 75 (6) : 1348-1354. ScholarBank@NUS Repository. https://doi.org/10.1021/ac0204909
Abstract: Two novel types of substituted cyclam-capped β-cyclodextrin (β-CD)-bonded silica particles have been prepared and used as chiral stationary phases in capillary electrochromatography (CEC). The two stationary phases have a chiral selector with three recognition sites: β-CD, cyclam, and the latter's sidearm. They exhibit excellent enantioselectivities in CEC for a wide range of compounds as a result of the cooperative functioning of the anchored β-CD and cyclam. After inclusion of the metal ion (Ni2+) from the running buffer into the substituted cyclams and their sidearm ligands, the bonded stationary phases become positively charged and can provide extra electrostatic interactions with ionizable solutes and enhance the dipolar interactions with some polar neutral solutes. This enhances the host-guest interaction with some solutes and improves chiral recognition and enantioselectivity. These new types of stationary phases exhibit great potential for fast chiral separations in CEC.
Source Title: Analytical Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/110839
ISSN: 00032700
DOI: 10.1021/ac0204909
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