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Title: Toxic epidermal necrolysis associated with TS-1 in a patient with gastric cancer
Authors: Tan, C.S.
Lim, R.
Lim, T.C.
Aw, C.W.
Yeo, S.W.
Lee, S.-C. 
Keywords: Gastric cancer
Toxic epidermal necrolysis
Issue Date: May-2011
Citation: Tan, C.S., Lim, R., Lim, T.C., Aw, C.W., Yeo, S.W., Lee, S.-C. (2011-05). Toxic epidermal necrolysis associated with TS-1 in a patient with gastric cancer. Japanese Journal of Clinical Oncology 41 (5) : 666-668. ScholarBank@NUS Repository.
Abstract: A 64-year-old female who has undergone D2 total gastrectomy was started on adjuvant treatment with TS-1. Four weeks after initiation of TS-1, the patient developed a rare complication of life-threatening toxic epidermal necrolysis. TS-1 was discontinued and the patient received treatment with intravenous immunoglobulin and supportive care with resolution of toxic epidermal necrolysis. TS-1 has been used for the treatment of gastric cancer, both in the adjuvant and metastatic setting, and is increasingly being used in other malignancies such as colon, pancreatic and non-small cell lung cancer. TS-1 is generally well tolerated. To our knowledge, this is the first reported case of toxic epidermal necrolysis associated with the usage of TS-1. © The Author (2011). Published by Oxford University Press. All rights reserved.
Source Title: Japanese Journal of Clinical Oncology
ISSN: 03682811
DOI: 10.1093/jjco/hyr032
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