Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep00642
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dc.titleIn situ differentiation of CD8α αt cells from CD4 T cells in peripheral lymphoid tissues
dc.contributor.authorNambu, Y.
dc.contributor.authorHayashi, T.
dc.contributor.authorJang, K.-J.
dc.contributor.authorAoki, K.
dc.contributor.authorMano, H.
dc.contributor.authorNakano, K.
dc.contributor.authorOsato, M.
dc.contributor.authorTakahashi, K.
dc.contributor.authorItoh, K.
dc.contributor.authorTeramukai, S.
dc.contributor.authorKomori, T.
dc.contributor.authorFujita, J.
dc.contributor.authorIto, Y.
dc.contributor.authorShimizu, A.
dc.contributor.authorSugai, M.
dc.date.accessioned2014-11-26T09:59:48Z
dc.date.available2014-11-26T09:59:48Z
dc.date.issued2012
dc.identifier.citationNambu, Y., Hayashi, T., Jang, K.-J., Aoki, K., Mano, H., Nakano, K., Osato, M., Takahashi, K., Itoh, K., Teramukai, S., Komori, T., Fujita, J., Ito, Y., Shimizu, A., Sugai, M. (2012). In situ differentiation of CD8α αt cells from CD4 T cells in peripheral lymphoid tissues. Scientific Reports 2 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep00642
dc.identifier.issn20452322
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110750
dc.description.abstractMutually exclusive cell fate determination of CD4 helper or CD8 killer T cells occurs in the thymus. These T-cell subsets are not believed to redirect other lineages. Here we showed that retinoic acid and transforming growth factor-Î 21 promoted the differentiation of CD8α α T cells from CD4 T cells in a Runx3-dependent manner. These cells were inferred to belong to immunoregulatory populations because subpopulations of CD8αα+TCRαβ T cells are known to suppress activated T cells, and mice with Runx3-/-' T cells showed defects during recovery from experimental allergic encephalomyelitis. Our results demonstrate that CD4 T cells play fundamental roles in controlling immune reactions through promotion and attenuation. We accordingly anticipate that clarifying the mechanisms underlying this process will provide insights leading to autoimmune and immunodeficiency disease therapies.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/srep00642
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1038/srep00642
dc.description.sourcetitleScientific Reports
dc.description.volume2
dc.description.page-
dc.identifier.isiut000308434900003
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