Please use this identifier to cite or link to this item: https://doi.org/10.3349/ymj.2009.50.4.464
DC FieldValue
dc.titleDivide and conquer: Progress in the molecular stratification of cancer
dc.contributor.authorTan, P.
dc.date.accessioned2014-11-26T09:06:01Z
dc.date.available2014-11-26T09:06:01Z
dc.date.issued2009-08
dc.identifier.citationTan, P. (2009-08). Divide and conquer: Progress in the molecular stratification of cancer. Yonsei Medical Journal 50 (4) : 464-473. ScholarBank@NUS Repository. https://doi.org/10.3349/ymj.2009.50.4.464
dc.identifier.issn05135796
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110700
dc.description.abstractCancer remains an outstanding cause of global morbidity and mortality, despite intensive research and unprecedented insights into the basic mechanisms of cancer development. A plethora of clinical and experimental evidence suggests that cancers from individual patients are likely to be molecularly heterogeneous in their use of distinct oncogenic pathways and biological programs. Efforts to significantly impact cancer patient outcomes will almost certainly require the development of robust strategies to subdivide such heterogeneous panels of cancers into biologically and clinically homogenous subgroups, for the purposes of personalizing treatment protocols and identifying optimal drug targets. In this review, I describe recent progress in the development of both targeted and genome-wide approaches for the molecular stratification of cancers, drawing examples from both the haematopoietic and solid tumor malignancies. © Copyright: Yonsei University College of Medicine 2009.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3349/ymj.2009.50.4.464
dc.sourceScopus
dc.subjectCancer genomics
dc.subjectMolecular stratification
dc.subjectTargeted therapies
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.3349/ymj.2009.50.4.464
dc.description.sourcetitleYonsei Medical Journal
dc.description.volume50
dc.description.issue4
dc.description.page464-473
dc.description.codenYOMJA
dc.identifier.isiut000269202800002
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